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Chem. Rev., Feb 29 2024, | https://doi.org/10.1021/acs.chemrev.3c00778 Theranostic Fluorescent Probes

Amit Sharma ¹, Peter Verwilst ², Mingle Li ³, Dandan Ma ^3,4, Nem Singh ⁵, Jiyoung Yoo ⁵, Yujin Kim ⁵, Ying Yang⁶, Jing-Hui Zhu ^3,4, Haiqiao Huang^3,4, Xi-Le Hu ⁷, Xiao-Peng He ^7,8, Lintao Zeng ⁶, Tony D James ^9,10, Xiaojun Peng ^3,11, Jonathan L Sessler ¹², Jong Seung Kim ^5,13

¹Amity School of Chemical Sciences, Amity University Punjab, Sector 82A, Mohali 140 306, India.

²Rega Institute for Medical Research, Medicinal Chemistry, KU Leuven, Herestraat 49, Box 1041, 3000 Leuven, Belgium.

³College of Materials Science and Engineering, Shenzhen University, Shenzhen 518060, China.

⁴College of Physics and Optoelectronic Engineering, Shenzhen University, Shenzhen 518060, China.

⁵Department of Chemistry, Korea University, Seoul 02841, Korea.

⁶School of Light Industry and Food Engineering, Guangxi University, Nanning, Guangxi 530004, China.

⁷Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering, Feringa Nobel Prize Scientist Joint Research Center, School of Chemistry and Molecular Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.

⁸National Center for Liver Cancer, the International Cooperation Laboratory on Signal Transduction, Eastern Hepatobiliary Surgery Hospital, Shanghai 200438, China.

⁹Department of Chemistry, University of Bath, Bath BA2 7AY, United Kingdom.

¹⁰School of Chemistry and Chemical Engineering, Henan Normal University, Xinxiang 453007, China.

¹¹State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China.

¹²Department of Chemistry, The University of Texas at Austin, Texas 78712-1224, United States.

¹³TheranoChem Incorporation, Seongbuk-gu, Seoul 02841, Korea.

A.S., P.V., M.L., D.M. contributed equally to this work.

Corresponding Authors : Amit Sharma, Xiao-Peng He, Lintao Zeng, Tony D. James, Xiaojun Peng, Jonathan L. Sessler, Jong Seung Kim

Abstract

The ability to gain spatiotemporal information, and in some cases achieve spatiotemporal control, in the context of drug delivery makes theranostic fluorescent probes an attractive and intensely investigated research topic. This interest is reflected in the steep rise in publications on the topic that have appeared over the past decade. Theranostic fluorescent probes, in their various incarnations, generally comprise a fluorophore linked to a masked drug, in which the drug is released as the result of certain stimuli, with both intrinsic and extrinsic stimuli being reported. This release is then signaled by the emergence of a fluorescent signal. Importantly, the use of appropriate fluorophores has enabled not only this emerging fluorescence as a spatiotemporal marker for drug delivery but also has provided modalities useful in photodynamic, photothermal, and sonodynamic therapeutic applications. In this review we highlight recent work on theranostic fluorescent probes with a particular focus on probes that are activated in tumor microenvironments. We also summarize efforts to develop probes for other applications, such as neurodegenerative diseases and antibacterials. This review celebrates the diversity of designs reported to date, from discrete small-molecule systems to nanomaterials. Our aim is to provide insights into the potential clinical impact of this still-emerging research direction.

논문정보

형식Review Paper
게재일2024년 02월 (BRIC 등록일 2024-03-11)
연구진국내(교신)+국외 연구진
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