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University of California, San Diego

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Adv. Sci., Mar 02 2024, | https://doi.org/10.1002/advs.202308237 Systemic Administration of Cowpea Mosaic Virus Demonstrates Broad Protection Against Metastatic Cancers

Young Hun Chung ^{1 2}, Zhongchao Zhao ^{2 3 4}, Eunkyeong Jung ³, Anthony O Omole ³, Hanyang Wang ⁵, Lucas Sutorus ³, Nicole F Steinmetz ^{1 2 3 4 6 7 8 9 *}

¹Department of Bioengineering, University of California, San Diego, La Jolla, CA, 92093, USA.

²Moores Cancer Center, University of California, San Diego, La Jolla, CA, 92093, USA.

³Department of NanoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.

⁴Center for Nano-ImmunoEngineering, University of California, San Diego, La Jolla, CA, 92093, USA.

⁵Department of Biology, University of California, San Diego, La Jolla, CA, 92093, USA.

⁶Department of Radiology, University of California, San Diego, La Jolla, CA, 92093, USA.

⁷Institute for Materials Discovery and Design, University of California, San Diego, La Jolla, CA, 92093, USA.

⁸Center for Engineering in Cancer, University of California, San Diego, La Jolla, CA, 92093, USA.

⁹Shu and K.C. Chien and Peter Farrell Collaboratory, University of California, San Diego, La Jolla, CA, 92093, USA.

^*Corresponding author: correspondence to Nicole F Steinmetz

Abstract

The key challenge in cancer treatment is prevention of metastatic disease which is therapeutically resistant and carries poor prognoses necessitating efficacious prophylactic approaches that prevent metastasis and recurrence. It is previously demonstrated that cowpea mosaic virus (CPMV) induces durable antitumor responses when used in situ, i.e., intratumoral injection. As a new direction, it is showed that CPMV demonstrates widespread effectiveness as an immunoprophylactic agent - potent efficacy is demonstrated in four metastatic models of colon, ovarian, melanoma, and breast cancer. Systemic administration of CPMV stimulates the innate immune system, enabling attack of cancer cells; processing of the cancer cells and associated antigens leads to systemic, durable, and adaptive antitumor immunity. Overall, CPMV demonstrated broad efficacy as an immunoprophylactic agent in the rejection of metastatic cancer.

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형식Research article
게재일2024년 03월 (BRIC 등록일 2024-03-29)
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