한빛사논문
- 조회402
양산 부산대학교 병원
Yerin Kang1†, Sieun Kim1†, Yunah Jung1†, Dai Sik Ko2, Hyun‑Woo Kim3, Jung‑Pil Yoon4, Sunghwan Cho5, Tae‑Jin Song6, Kihun Kim8* , Eunjeong Son9* and Yun Hak Kim7,8*
1School of Medicine, Pusan National University, Yangsan, Republic of Korea.
2Division of Vascular Surgery, Department of General Surgery, Gachon University Gil Medical Center, Incheon, Republic of Korea.
3Department of Neurology, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
4Department of Anesthesia and Pain Medicine, Pusan National University Yangsan Hospital, Yangsan, Korea.
5Department of Surgery, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
6Department of Neurology, Seoul Hospital, Ewha Womans University College of Medicine, Seoul, Republic of Korea.
7Department of Biomedical Informatics, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
8Department of Anatomy, School of Medicine, Pusan National University, Yangsan, Republic of Korea.
9Division of Respiratory and Allergy, Department of Internal Medicine, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea.
†Yerin Kang, Sieun Kim, and Yunah Jung contributed equally to this work as first authors.
*Correspondence: Kihun Kim, Eunjeong Son, Yun Hak Kim
Abstract
Background
Epilepsy, characterized by recurrent unprovoked seizures, poses significant challenges to affected individuals globally. While several established risk factors for epilepsy exist, the association with cigarette smoking remains debated. This study aims to conduct systematic review and meta-analysis to elucidate the potential association between smoking and the likelihood of epilepsy.
Methods
The search was performed on March 31st, 2023, using the Medline, Embase, Web of Science, Scopus, and ScienceDirect. We included cohort, cross-sectional, and case–control studies in our meta-analysis, conducting subgroup analyses based on smoking history, sex, and epilepsy type to yield specific insights.
Results
We identified 2550 studies, of which 17 studies were finally included in this study. The pooled odds ratio of epilepsy was 1.14 (0.96–1.36) in smokers compared to non-smokers. In current smokers compared to non-smokers, the odds ratio was 1.46 (1.13–1.89), while, in former smokers compared to non-smokers, the odds ratio was 1.14 (0.83–1.56).
Conclusions
While the overall association between smoking and epilepsy did not reach statistical significance, a notable association was found among current smokers. The study emphasizes the importance of smoking cessation as a potential preventive measure against epilepsy, especially given the proconvulsive effects of nicotine. Future research should address limitations and explore specific clinical scenarios to enhance our understanding of the complex relationship between cigarette use and epilepsy.
논문정보
- Research article
- 2024년 03월 (BRIC 등록일 2024-03-04)
- 국내 연구진
- 의약학 > 유전 및 유전체의학
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