정현호 (연세대학교 의과대학)

한빛사논문

조회290

연세대학교 의과대학

Nat. Commun., Feb 27 2024, 15 (1) | https://doi.org/10.1038/s41467-024-45768-0 In-vivo integration of soft neural probes through high-resolution printing of liquid electronics on the cranium

Young-Geun Park^1,2,8, Yong Won Kwon^1,2,8, Chin Su Koh^3,8, Enji Kim^1,2,8, Dong Ha Lee^1,2, Sumin Kim^1,2, Jongmin Mun⁴, Yeon-Mi Hong^1,2, Sanghoon Lee^1,2, Ju-Young Kim^2,5, Jae-Hyun Lee^2,5, Hyun Ho Jung³, Jinwoo Cheon^2,5,6, Jin Woo Chang⁷ & Jang-Ung Park^1,2,3,5

¹Department of Materials Science and Engineering, Yonsei University, Seoul 03722, South Korea.

²Center for Nanomedicine, Institute for Basic Science (IBS), Seoul 03722, South Korea.

³Department of Neurosurgery, Yonsei University College of Medicine, Seoul 03722, South Korea.

⁴Department of Statistics and Data Science, Yonsei University, Seoul 03722, South Korea.

⁵Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, South Korea.

⁶Department of Chemistry, Yonsei University, Seoul 03722, South Korea.

⁷Department of Neurosurgery, Korea University Anam Hospital, Seoul 02841, South Korea.

⁸These authors contributed equally: Young-Geun Park, Yong Won Kwon, Chin Su Koh, Enji Kim.

Corresponding authors : Correspondence to Hyun Ho Jung, Jinwoo Cheon, Jin Woo Chang or Jang-Ung Park.

Abstract

Current soft neural probes are still operated by bulky, rigid electronics mounted to a body, which deteriorate the integrity of the device to biological systems and restrict the free behavior of a subject. We report a soft, conformable neural interface system that can monitor the single-unit activities of neurons with long-term stability. The system implements soft neural probes in the brain, and their subsidiary electronics which are directly printed on the cranial surface. The high-resolution printing of liquid metals forms soft neural probes with a cellular-scale diameter and adaptable lengths. Also, the printing of liquid metal-based circuits and interconnections along the curvature of the cranium enables the conformal integration of electronics to the body, and the cranial circuit delivers neural signals to a smartphone wirelessly. In the in-vivo studies using mice, the system demonstrates long-term recording (33 weeks) of neural activities in arbitrary brain regions. In T-maze behavioral tests, the system shows the behavior-induced activation of neurons in multiple brain regions.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-02-29)
연구진국내 연구진
분야 의약학 > 응용의학

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