김소희 (서울대학교)

한빛사논문

조회396

서울대학교

Sci. Adv., Mar 2024, 10 (9) | https://doi.org/10.1126/sciadv.adk6425 Rise in broadly cross-reactive adaptive immunity against human β-coronaviruses in MERS-recovered patients during the COVID-19 pandemic

So-Hee Kim ^1,2†, Yuri Kim 1,2,3†, Sangeun Jeon ^4†, Uni Park ^1,2, Ju-Il Kang ³, Kyeongseok Jeon ^1,2, Hye-Ran Kim ^1,2, Songhyeok Oh ^1,2, Ji-Young Rhee ⁵, Jae-Phil Choi⁶, Wan Beom Park ⁷, Sang Won Park ⁷, Jeong-Sun Yang ⁸, Joo-Yeon Lee ⁸, Jihye Kang ⁹, Hyoung-Shik Shin ¹⁰, Yeonjae Kim ¹¹, Seungtaek Kim ^4*, Yeon-Sook Kim ^12*, Dong-Gyun Lim ^9*, Nam-Hyuk Cho ^1,2,3,13*

¹Department of Microbiology and Immunology, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

²Department of Biomedical Sciences, College of Medicine, Seoul National University, Seoul 03080, Republic of Korea.

³Institute of Endemic Disease, Seoul National University Medical Research, Seoul 03080, Republic of Korea.

⁴Zoonotic Virus Laboratory, Institut Pasteur Korea, Seongnam 13488, Republic of Korea.

⁵Division of Infectious Diseases, Department of Medicine, Dankook University College of Medicine, Cheonan 31116, Republic of Korea.

⁶Department of Internal Medicine, Seoul Medical Center, Seoul 02053, Republic of Korea.

⁷Department of Internal Medicine, Seoul National University College of Medicine, Seoul 03080, Republic of Korea.

⁸Center for Emerging Virus Research, Korea National Institute of Health, Korea Disease Control and Prevention Agency, Cheongju 28159, Republic of Korea.

⁹Translational Research Center, Research Institute of Public Health, National Medical Center, Seoul 04564, Republic of Korea.

¹⁰Division of Infectious Diseases, Department of Internal Medicine, Daejeon Eulji Medical Center, Eulji University School of Medicine, Daejeon 34824, Republic of Korea.

¹¹Center for Infectious Diseases, National Medical Center, Seoul 04564, Republic of Korea.

¹²Division of Infectious Diseases, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon 35015, Republic of Korea.

¹³Seoul National University Bundang Hospital, Seongnam, Gyeonggi-do 13620, Republic of Korea.

^*corresponding authors: Seungtaek Kim, Yeon-Sook Kim, Dong-Gyun Lim, Nam-Hyuk Cho

^†these authors contributed equally to this work.

Abstract

To develop a universal coronavirus (CoV) vaccine, long-term immunity against multiple CoVs, including severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variants, Middle East respiratory syndrome (MERS)-CoV, and future CoV strains, is crucial. Following the 2015 Korean MERS outbreak, we conducted a long-term follow-up study and found that although neutralizing antibodies and memory T cells against MERS-CoV declined over 5 years, some recovered patients exhibited increased antibody levels during the COVID-19 pandemic. This likely resulted from cross-reactive immunity induced by SARS-CoV-2 vaccines or infections. A significant correlation in antibody responses across various CoVs indicates shared immunogenic epitopes. Two epitopes-the spike protein's stem helix and intracellular domain-were highly immunogenic after MERS-CoV infection and after SARS-CoV-2 vaccination or infection. In addition, memory T cell responses, especially polyfunctional CD4 ⁺ T cells, were enhanced during the pandemic, correlating significantly with MERS-CoV spike-specific antibodies and neutralizing activity. Therefore, incorporating these cross-reactive and immunogenic epitopes into pan-CoV vaccine formulations may facilitate effective vaccine development.

논문정보

형식Research article
게재일2024년 03월 (BRIC 등록일 2024-02-29)
연구진국내 연구진
분야 의약학 > 감염의학

댓글 작성 로그인

CV 열람하기

연락처 보기