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Ann. Rheum. Dis., Feb 27 2024, ard-2024-225492 | https://doi.org/10.1136/ard-2024-225492
What rheumatologists need to know about mRNA vaccines: current status and future of mRNA vaccines in autoimmune inflammatory rheumatic diseases
Jin Kyun Park1, Eun Bong Lee2, Kevin L Winthrop3
1Rheumatology, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea (the Republic of)
2Internal Medicine, Seoul National University College of Medicine, Jongno-gu, Seoul, Korea (the Republic of)
3School of Public Health, Oregon Health & Science University, Portland, Oregon, USA
Correspondence to Dr Kevin L Winthrop
Abstract
Messenger RNA (mRNA) vaccines as a novel vaccine platform offer new tools to effectively combat both emerging and existing pathogens which were previously not possible. The 'plug and play' feature of mRNA vaccines enables swift design and production of vaccines targeting complex antigens and rapid incorporation of new vaccine constituents as needed. This feature makes them likely to be adopted for widespread clinical use in the future.Currently approved mRNA vaccines include only those against SARS-CoV-2 virus. These vaccines demonstrate robust immunogenicity and offer substantial protection against severe disease. Numerous mRNA vaccines against viral pathogens are in the early to late phase of development. Several mRNA vaccines for influenza are tested in clinical trials, with some already in phase 3 studies. Other vaccines in the early and late phases of development include those targeting
Cytomegalovirus, varicella zoster virus, respiratory syncytial virus and Epstein-Barr virus. Many of these vaccines will likely be indicated for immunosuppressed populations including those with autoimmune inflammatory rheumatic diseases (AIIRD). This review focuses on the mechanism, safety and efficacy of mRNA in general and summarises the status of mRNA vaccines in development for common infectious diseases of particular interest for patients with AIIRD.
논문정보
- Review Paper
- 2024년 02월 (BRIC 등록일 2024-03-11)
- 국내+국외 연구진
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