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Bioact. Mater., Available online 19 February 2024 | https://doi.org/10.1016/j.bioactmat.2024.01.027 Immunotherapy targeting the obese white adipose tissue microenvironment: Focus on non-communicable diseases

Lia Priscilla ^a,1, Chaerim Yoo ^a,1, Seonmi Jang ^a, Sewon Park ^a, Gayoung Lim ^a, Taekyun Kim ^a, Dong Yun Lee^a,b,c

^aDepartment of Bioengineering, College of Engineering, and BK FOUR Biopharmaceutical Innovation Leader for Education and Research Group, Hanyang University, Seoul, 04763, Republic of Korea

^bInstitute of Nano Science and Technology (INST) & Institute for Bioengineering and Biopharmaceutical Research (IBBR), Hanyang University, Seoul, 04763, Republic of Korea

^cElixir Pharmatech Inc., Seoul, 07463, Republic of Korea

¹Contributed equally to this study.

Corresponding author: Dong Yun Lee

Abstract

Obesity triggers inflammatory responses in the microenvironment of white adipose tissue, resulting in chronic systemic inflammation and the subsequent development of non-communicable diseases, including type 2 diabetes, coronary heart disease, and breast cancer. Current therapy approaches for obesity-induced non-communicable diseases persist in prioritizing symptom remission while frequently overlooking the criticality of targeting and alleviating inflammation at its source. Accordingly, this review highlights the importance of the microenvironment of obese white adipose tissue and the promising potential of employing immunotherapy to target it as an effective therapeutic approach for non-communicable diseases induced by obesity. Additionally, this review discusses the challenges and offers perspective about the immunotherapy targeting the microenvironment of obese white adipose tissue.

논문정보

형식Review Paper
게재일2024년 02월 (BRIC 등록일 2024-02-27)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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