김보람 (University of Pennsylvania)

한빛사논문

조회243

University of Pennsylvania

Alzheimers. Dement., Feb 23 2024, | https://doi.org/10.1002/alz.13736 Neighborhood disadvantage reduces cognitive reserve independent of neuropathologic change

Boram Kim ¹, Isabel Yannatos ², Kaitlin Blam¹, Douglas Wiebe ³, Sharon X Xie⁴, Corey T McMillan², Dawn Mechanic-Hamilton ⁵, David A Wolk ⁵, Edward B Lee¹

¹Translational Neuropathology Research Laboratory, Department of Pathology and Laboratory Medicine, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

²Penn Frontotemporal Degeneration Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

³Department of Emergency Medicine, Department of Epidemiology, University of Michigan, Ann Arbor, Michigan, USA.

⁴Department of Biostatistics, Epidemiology and Informatics, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

⁵Penn Memory Center, Department of Neurology, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, Pennsylvania, USA.

CORRESPONDING AUTHOR : Edward B. Lee

Abstract

Individuals in socioeconomically disadvantaged neighborhoods exhibit increased risk for impaired cognitive function. Whether this association relates to the major dementia-related neuropathologies is unknown. This cross-sectional study included 469 autopsy cases from 2011 to 2023. The relationships between neighborhood disadvantage measured by Area Deprivation Index (ADI) percentiles categorized into tertiles, cognition evaluated by the last Mini-Mental State Examination (MMSE) scores before death, and 10 dementia-associated proteinopathies and cerebrovascular disease were assessed using regression analyses. Higher ADI was significantly associated with lower MMSE score. This was mitigated by increasing years of education. ADI was not associated with an increase in dementia-associated neuropathologic change. Moreover, the significant association between ADI and cognition remained even after controlling for changes in major dementia-associated proteinopathies or cerebrovascular disease. Neighborhood disadvantage appears to be associated with decreased cognitive reserve. This association is modified by education but is independent of the major dementia-associated neuropathologies.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-02-27)
연구진국외 연구진
분야 의약학 > 신경의학

댓글 작성 로그인

CV 열람하기

연락처 보기