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조회511

한국화학연구원

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Environ. Int., Feb 20 2024, 185 S0160-4120(24)00108-9 | https://doi.org/10.1016/j.envint.2024.108522 Maternal nanoplastic ingestion induces an increase in offspring body weight through altered lipid species and microbiota

Bohyeon Jeong^a, Ji-Sun Kim ^b, A Ra Kwon ^c, Jangjae Lee ^c,d, Subin Park ^a, Jahong Koo ^a,e, Wang Sik Lee ^f, Jeong Yeob Baek ^a, Won-Ho Shin ^g, Jung-Sook Lee ^b,e, Jinyoung Jeong ^e,f, Won Kon Kim ^e,h, Cho-Rok Jung ^e,i, Nam-Soon Kim ^a,e, Sung-Hee Cho ^c, Da Yong Lee ^a,e

^aRare Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, South Korea

^bKorean Collection for Type Cultures, Korea Research Institute of Bioscience and Biotechnology (KRIBB), Jeongeup, 56212, South Korea

^cChemical Analysis Center, Korea Research Institute of Chemical Technology (KRICT), Daejeon 34114, South Korea

^dDepartment of Chemistry, Korea University, Seoul 02841, South Korea

^eKRIBB School, Korea University of Science and Technology (UST), Daejeon, South Korea

^fEnvironmental Disease Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, South Korea

^gDepartment of Predictive Toxicology, Korea Institute of Toxicology, Daejeon 34114, South Korea

^hMetabolic Regulation Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, South Korea

ⁱStem Cell Convergence Research Center, Korea Research Institute of Bioscience and Biotechnology (KRIBB), 125 Gwahak-ro, Yuseong-gu, Daejeon 34141, South Korea

Corresponding authors: Sung-Hee Cho, Da Yong Lee

Abstract

The rapidly increasing prevalence of obesity and overweight, especially in children and adolescents, has become a serious societal issue. Although various genetic and environmental risk factors for pediatric obesity and overweight have been identified, the problem has not been solved. In this study, we examined whether environmental nanoplastic (NP) pollutants can act as environmental obesogens using mouse models exposed to NPs derived from polystyrene and polypropylene, which are abundant in the environment. We found abnormal weight gain in the progeny until 6 weeks of age following the oral administration of NPs to the mother during gestation and lactation. Through a series of experiments involving multi-omic analyses, we have demonstrated that NP-induced weight gain is caused by alterations in the lipid composition (lysophosphatidylcholine/phosphatidylcholine ratio) of maternal breast milk and he gut microbiota distribution of the progeny. These data indicate that environmental NPs can act as obesogens in childhood.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-02-26)
연구진국내 연구진
분야 생명과학 > 신경생물학

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