Tien Thuy Phan (IBS, UST) | 한빛사논문 > 한빛사

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Tien Thuy PhanTien Thuy Phan

IBS, UST

Sci. Adv., Feb 23 2024, 10 (8) eadk3198 | https://doi.org/10.1126/sciadv.adk3198 Long-lasting forms of plasticity through patterned ultrasound-induced brainwave entrainment

Ho-Jeong Kim^1,2†, Tien Thuy Phan ^1,3†, Keunhyung Lee ^4,5, Jeong Sook Kim⁶, Sang-Yeong Lee ^1,3, Jung Moo Lee ¹, Jongrok Do ¹^,7, Doyun Lee ¹, Sung-Phil Kim ², Kyu Pil Lee ⁶, Jinhyoung Park^4,5,5, C Justin Lee^1,2,3, Joo Min Park^1,2,3

¹Center for Cognition and Sociality, Institute for Basic Science, Daejeon, Republic of Korea.

²Department of Biomedical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan, Republic of Korea.

³University of Science and Technology (UST), Daejeon, Republic of Korea.

⁴Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University, Suwon, Republic of Korea.

⁵Department of Biomedical Engineering, Sungkyunkwan University, Suwon, Republic of Korea.

⁶Department of Physiology, College of Veterinary Medicine, Chungnam National University, Daejeon, Republic of Korea.

⁷Department of Biological Sciences, Korea Advanced Institute of Science and Technology, Daejeon 34141, Republic of Korea.

^†These authors contributed equally to this work.

^*Corresponding author: Joo Min Park

Abstract

Achieving long-lasting neuronal modulation with low-intensity, low-frequency ultrasound is challenging. Here, we devised theta burst ultrasound stimulation (TBUS) with gamma bursts for brain entrainment and modulation of neuronal plasticity in the mouse motor cortex. We demonstrate that two types of TBUS, intermittent and continuous TBUS, induce bidirectional long-term potentiation or depression-like plasticity, respectively, as evidenced by changes in motor-evoked potentials. These effects depended on molecular pathways associated with long-term plasticity, including N-methyl-d-aspartate receptor and brain-derived neurotrophic factor/tropomyosin receptor kinase B activation, as well as de novo protein synthesis. Notably, bestrophin-1 and transient receptor potential ankyrin 1 play important roles in these enduring effects. Moreover, pretraining TBUS enhances the acquisition of previously unidentified motor skills. Our study unveils a promising protocol for ultrasound neuromodulation, enabling noninvasive and sustained modulation of brain function.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-02-27)
연구진국내 연구진
분야 의약학 > 신경의학

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