Mrudulakumari Vasudevan Ushasree (경희대학교) | 한빛사논문 > 한빛사

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Mrudulakumari Vasudevan UshasreeMrudulakumari Vasudevan Ushasree

경희대학교

Biotechnol. Adv., Feb 21 2024, S0734-9750(24)00019-3 | https://doi.org/10.1016/j.biotechadv.2024.108325 New opportunities and perspectives on biosynthesis and bioactivities of secondary metabolites from Aloe vera

Mrudulakumari Vasudevan Ushasree ^a, Qi Jia ^b, Seon Gil Do ^c, Eun Yeol Lee ^a

^aDepartment of Chemical Engineering (BK21 FOUR Integrated Engineering Program), Kyung Hee University, Yongin-si, Gyeonggi-do 17104, Republic of Korea

^bUnigen, Inc., 2121 South street suite 400 Tacoma, Washington 98405, USA

^cNaturetech, Inc., 29-8, Yongjeong-gil, Chopyeong-myeon, Jincheon-gun, Chungcheongbuk-do 27858, Republic of Korea

Corresponding author : Eun Yeol Lee

Abstract

Historically, the genus Aloe has been an indispensable part of both traditional and modern medicine. Decades of intensive research have unveiled the major bioactive secondary metabolites of this plant. Recent pandemic outbreaks have revitalized curiosity in aloe metabolites, as they have proven pharmacokinetic profiles and repurposable chemical space. However, the structural complexity of these metabolites has hindered scientific advances in the chemical synthesis of these compounds. Multi-omics research interventions have transformed aloe research by providing insights into the biosynthesis of many of these compounds, for example, aloesone, aloenin, noreugenin, aloin, saponins, and carotenoids. Here, we summarize the biological activities of major aloe secondary metabolites with a focus on their mechanism of action. We also highlight the recent advances in decoding the aloe metabolite biosynthetic pathways and enzymatic machinery linked with these pathways. Proof-of-concept studies on in vitro, whole-cell, and microbial synthesis of aloe compounds have also been briefed. Research initiatives on the structural modification of various aloe metabolites to expand their chemical space and activity are detailed. Further, the technological limitations, patent status, and prospects of aloe secondary metabolites in biomedicine have been discussed.

논문정보

형식Review Paper
게재일2024년 02월 (BRIC 등록일 2024-02-26)
연구진국내(교신)+국외 연구진
분야 생명과학 > 생물공학

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