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Transl. Neurodegener., Feb 20 2024, 13 (1) | https://doi.org/10.1186/s40035-024-00402-3
Emerging role of senescent microglia in brain aging-related neurodegenerative diseases
Chan Rim1†, Min‑Jung You1†, Minyeop Nahm3 and Min‑Soo Kwon1,2*
1Department of Pharmacology, Research Institute for Basic Medical Science, School of Medicine, CHA University, CHA Bio Complex, 335 Pangyo, Bundang‑gu, Seongnam‑si, Gyeonggi‑do 13488, Republic of Korea
2Brainimmunex Inc., 26 Yatap‑ro, Bundang‑gu, Seongnam‑si, Gyeonggi‑do 13522, Republic of Korea
3Dementia Research Group, Korea Brain Research Institute, Daegu, Republic of Korea
†Chan Rim and Min-Jung You contributed equally to this review
*Correspondence: Min‑Soo Kwon
Abstract
Brain aging is a recognized risk factor for neurodegenerative diseases like Alzheimer's disease, Parkinson's disease, and amyotrophic lateral sclerosis (ALS, Lou Gehrig's disease), but the intricate interplay between brain aging and the pathogenesis of these conditions remains inadequately understood. Cellular senescence is considered to contribute to cellular dysfunction and inflammaging. According to the threshold theory of senescent cell accumulation, the vulnerability to neurodegenerative diseases is associated with the rates of senescent cell generation and clearance within the brain. Given the role of microglia in eliminating senescent cells, the accumulation of senescent microglia may lead to the acceleration of brain aging, contributing to inflammaging and increased vulnerability to neurodegenerative diseases. In this review, we propose the idea that the senescence of microglia, which is notably vulnerable to aging, could potentially serve as a central catalyst in the progression of neurodegenerative diseases. The senescent microglia are emerging as a promising target for mitigating neurodegenerative diseases.
논문정보
- Review Paper
- 2024년 02월 (BRIC 등록일 2024-02-22)
- 국내 연구진
- 의약학 > 분자세포의학
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