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Angew. Chem.-Int. Edit., Feb 19 2024, | https://doi.org/10.1002/anie.202400249
Cell Membrane as A Promising Therapeutic Target: From Materials Design to Biomedical Applications
Xiaofeng Wu 1, Jing-Jing Hu 2, Juyoung Yoon 3
1Southeast University, State Key Laboratory of Digital Medical Engineering, School of Biological Science and Medical Engineering, CHINA.
2China University of Geosciences, State Key Laboratory of Biogeology Environmental Geology, Engineering Research Center of Nano-Geomaterials of Ministry of Education, Faculty of Materials Science and Chemistry, CHINA.
3Ewha Womans University, Department of Chemistry, 11-1 Daehyun-Dong, Seodaemun-Gu, 120-750, Seoul, KOREA, REPUBLIC OF.
CORRESPONDING AUTHOR : Juyoung Yoon
Abstract
The cell membrane is a crucial component of cells, protecting their integrity and stability while facilitating signal transduction and information exchange. Therefore, disrupting its structure or impairing its functions can potentially cause irreversible cell damage. Presently, the tumor cell membrane is recognized as a promising therapeutic target for various treatment methods. Given the extensive research focused on cell membranes, it is both necessary and timely to discuss these developments, from materials design to specific biomedical applications. This review covers treatments based on functional materials targeting the cell membrane, ranging from well-known membrane-anchoring photodynamic therapy to recent lysosome-targeting chimaeras for protein degradation. The diverse therapeutic mechanisms are introduced in the following sections: membrane-anchoring phototherapy, self-assembly on the membrane, in situ biosynthesis on the membrane, and degradation of cell membrane proteins by chimeras. In each section, we outline the conceptual design or general structure derived from numerous studies, emphasizing representative examples to understand advancements and draw inspiration. Finally, we discuss some challenges and future directions in membrane-targeted therapy from our perspective. This review aims to engage multidisciplinary readers and encourage researchers in related fields to advance the fundamental theories and practical applications of membrane-targeting therapeutic agents.
논문정보
- Research article
- 2024년 02월 (BRIC 등록일 2024-02-23)
- 국내(교신)+국외 연구진
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