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박종웅Jong Woong Park

고려대학교 안암병원

Adv. Mater., Jan 26 2024, | https://doi.org/10.1002/adma.202307810 Sticky and Strain-Gradient Artificial Epineurium for Sutureless Nerve Repair in Rodents and Nonhuman Primates

Duhwan Seong ^1,2, Yeonsun Choi ^2,3, In Cheul Choi ⁴, Jaebeom Lee ^2,5, Jae Hyuk Choi⁵, Ji Hun Park ⁴, Jae Jun Nam⁴, Jaewon Ju ^2,5, Hyun Jae Ryoo ⁴, Donghee Kwak⁴, Joonyeol Lee ^2,3, Seong-Gi Kim ^2,3, Dong Hwee Kim ⁶, Jong Woong Park ⁴, Mikyung Shin ^2,3,5, Donghee Son^1,2,7

¹Department of Electrical and Computer Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

²Center for Neuroscience Imaging Research, Institute for Basic Science (IBS), Suwon, 16419, Republic of Korea.

³Department of Biomedical Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

⁴Department of Orthopedic Surgery, College of Medicine, Korea University Anam Hospital, 73, Goryedae-ro, Sungbuk-gu, Seoul, 06334, Republic of Korea.

⁵Department of Intelligent Precision Healthcare Convergence, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

⁶Department of Physical Medicine and Rehabilitation, College of Medicine, Korea University Ansan Hospital, Ansan, 15355, Republic of Korea.

⁷Department of Superintelligence Engineering, Sungkyunkwan University (SKKU), Suwon, 16419, Republic of Korea.

D.S., Y.C., and I.C.C. contributed equally to this work.

CORRESPONDING AUTHORS : Jong Woong Park, Mikyung Shin, Donghee Son

Abstract

The need for the development of soft materials capable of stably adhering to nerve tissues without any suturing followed by additional damages is at the fore at a time when success in postoperative recovery depends largely on the surgical experience and/or specialized microsuturing skills of the surgeon. Despite fully recognizing such prerequisite conditions, designing the materials with robust adhesion to wet nerves as well as acute/chronic anti-inflammation remains to be resolved. Herein, a sticky and strain-gradient artificial epineurium (SSGAE) that overcomes the most critically challenging aspect for realizing sutureless repair of severely injured nerves is presented. In this regard, the SSGAE with a skin-inspired hierarchical structure entailing strain-gradient layers, anisotropic Janus layers including hydrophobic top and hydrophilic bottom surfaces, and synergistic self-healing capabilities enables immediate and stable neurorrhaphy in both rodent and nonhuman primate models, indicating that the bioinspired materials strategy significantly contributes to translational medicine for effective peripheral nerve repair.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-02-19)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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