한빛사논문
- 조회347
Jung Eun Yoo MD, PhD a,b, Miso Kim MD c, Bongseong Kim PhD d, Heesun Lee MD, PhD e, Won Hyuk Chang MD, PhD f, Jeehyun Yoo MD, PhD g, Kyungdo Han PhD d∗, Dong Wook Shin MD, MBA, DrPH c,h∗
aDepartment of Family Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea
bDepartment of Family Medicine, Seoul National University College of Medicine, Seoul, Republic of Korea
cSupportive Care Center/Department of Family Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
dDepartment of Statistics and Actuarial Science, Soongsil University, Seoul, Republic of Korea
eDivision of Cardiology, Department of Internal Medicine, Healthcare System Gangnam Center, Seoul National University Hospital, Seoul, Republic of Korea
fDepartment of Physical and Rehabilitation Medicine, Center for Prevention and Rehabilitation, Heart Vascular Stroke Institute, Samsung Medical Center Sungkyunkwan University School of Medicine, Seoul, Republic of Korea
gDepartment of Physical Medicine and Rehabilitation, Inje University Ilsan Paik Hospital, Gyeonggi, Republic of Korea
hDepartment of Clinical Research Design and Evaluation, Samsung Advanced Institute for Health Science and Technology (SAIHST), Sungkyunkwan University, Seoul, Republic of Korea
Address for correspondence: Dr Kyungdo Han, Dr Dong Wook Shin
Abstract
Background: Heart diseases are a growing concern for the spinal cord injury (SCI) population.
Objectives: This study aims to compare the incidence of heart diseases between SCI survivors and the general non-SCI population.
Methods: We identified 5,083 SCI survivors and 1:3 age- and sex-matched non-SCI controls. Study outcomes were myocardial infarction (MI), heart failure (HF), and atrial fibrillation (AF). The cohort was followed up from the index date (diagnosis date for SCI or corresponding date for matched controls) until 2019.
Results: SCI survivors showed a higher risk for MI (adjusted HR [aHR]: 2.41; 95% CI: 1.93-3.00), HF (aHR: 2.24; 95% CI: 1.95-2.56), and AF (aHR: 1.84; 95% CI: 1.49-2.28) compared to controls. The risks were further increased for those who were registered in the National Disability Registry within 1 year from the index date (SCI survivors with disability): SCI survivors with severe disability had the highest risks of MI (aHR: 3.74; 95% CI: 2.43-5.76), HF (aHR: 3.96; 95% CI: 3.05-5.14), and AF (aHR: 3.32; 95% CI: 2.18-5.05). Cervical and lumbar SCI survivors had an increased risk of heart disease regardless of disability compared to matched controls; these risks were slightly higher in those with disability. Thoracic SCI survivors with disability had significantly increased risk of heart disease compared to matched controls.
Conclusions: SCI survivors at all levels were at significantly greater risk for heart disease than non-SCI controls, particularly those with severe disability. Clinicians must be aware of the importance of heart disease in SCI survivors.
논문정보
- Research article
- 2024년 02월 (BRIC 등록일 2024-02-16)
- 국내 연구진
- 의약학 > 종양의학
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