한빛사논문
- 조회534
Jiyeon Leem 1, Crystal Lee 1, Da Yi Choi 1 and Jeong Su Oh 1,*
1Department of Integrative Biotechnology, Sungkyunkwan University, Suwon, South Korea.
*Corresponding author: correspondence to Jeong Su Oh
Abstract
DNA damage is a critical threat that poses significant challenges to all cells. To address this issue, cells have evolved a sophisticated molecular and cellular process known as the DNA damage response (DDR). Among the various cell types, mammalian oocytes, which remain dormant in the ovary for extended periods, are particularly susceptible to DNA damage. The occurrence of DNA damage in oocytes can result in genetic abnormalities, potentially leading to infertility, birth defects, and even abortion. Therefore, understanding how oocytes detect and repair DNA damage is of paramount importance in maintaining oocyte quality and preserving fertility. Although the fundamental concept of the DDR is conserved across various cell types, an emerging body of evidence reveals striking distinctions in the DDR between mammalian oocytes and somatic cells. In this review, we highlight the distinctive characteristics of the DDR in oocytes and discuss the clinical implications of DNA damage in oocytes.
논문정보
- Review Paper
- 2024년 02월 (BRIC 등록일 2024-02-15)
- 국내 연구진
- 생명과학 > 세포생물학
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