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김수미Soomi Kim
이노테라피
Adv. Healthc. Mater., Feb 09 2024, | https://doi.org/10.1002/adhm.202304004
Coagulant Protein-Free Blood Coagulation Using Catechol-Conjugated Adhesive Chitosan/Gelatin Double Layer
Soomi Kim 1, Keumyeon Kim 1, Mi-Young Koh 1, Minjae Do 2, Moon Sue Lee 1, Ji Hyun Ryu 3, Haeshin Lee 2
1R&D Center, InnoTherapy Inc., 25 Seonyu-ro 13-gil, Yeongdeungpo-gu, Seoul, 07282, Republic of Korea.
2Department of Chemistry, Korea Advanced Institute of Science and Technology, 291 Daehak-ro, Yuseong-gu, Daejeon, 34141, Republic of Korea.
3Department of Carbon Convergence Engineering, Wonkwang University, 460 Iksan-daero, Jeollabuk, Iksan, 54538, Republic of Korea.
CORRESPONDING AUTHORS : Ji Hyun Ryu, Haeshin Lee
Abstract
Since the discovery of polyphenolic underwater adhesion in marine mussels, researchers have striven to emulate this natural phenomenon in the development of adhesive hemostatic materials. In our study, we develop bio-inspired hemostatic materials that lead to pseudo-active blood coagulation, utilizing traditionally passive polymer matrices of chitosan and gelatin. The two-layer configuration, consisting of a thin, blood-clotting CHI-C layer and a thick, barrier-functioning gelatin ad-layer (CHI-C/Geln), maximizes hemostatic capability and usability. The unique combination of coagulant protein-free condition with CHI-C showcases not only coagulopathy-independent blood clotting properties (efficacy) but also exceptional clinical potential, meeting all necessary biocompatibility evaluation (safety) without inclusion of conventional coagulation triggering proteins such as thrombin or fibrinogen. As a result, the CHI-C/Geln has been approved by the Ministry of Food and Drug Safety (MFDS, Republic of Korea) as a class II medical device. Hemostatic efficacy observed in multiple animal models further demonstrates the superiority of CHI-C/Geln sponges in achieving quick hemostasis compared to standard treatments. Our study not only enriches the growing body of research on mussel-inspired materials but also emphasizes the potential of biomimicry in developing advanced medical materials, contributing a promising avenue toward development of readily accessible and affordable hemostatic materials. This article is protected by copyright. All rights reserved.
논문정보
- Research article
- 2024년 02월 (BRIC 등록일 2024-02-14)
- 국내 연구진
- 바이오·의료융합 > 바이오센싱 및 나노바이오물질
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