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백지현Jihyun Baek

차의과학대학교

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Biomark. Res., Feb 08 2024, 12 (1) 22 | https://doi.org/10.1186/s40364-023-00553-x Association between circulating ECM-associated molecules and cardiovascular outcomes in hemodialysis patients: a multicenter prospective cohort study

Hyeon Seok Hwang^1†, Jihyun Baek^2,3†, So-Young Lee², Hye Yun Jeong², Jin Sug Kim¹, Yang Gyun Kim⁴, ShinYoung Ahn⁵, Kipyo Kim⁶, Seok Hui Kang⁷, Min-Jeong Lee⁸, Dong-Young Lee⁹ and Yu Ho Lee^2*

¹Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital, College of Medicine, Kyung Hee University, Seoul, Korea

²Division of Nephrology, Department of Internal Medicine, CHA Bundang Medical Center, CHA University School of Medicine, CHA Bundang Medical Center, 59 Yatap-ro, Bundang-gu, Seongnam-si, Republic of Korea

³Department of Biomedical Science, College of Life Science, CHA University, Pocheon, Republic of Korea

⁴Division of Nephrology, Department of Internal Medicine, Kyung Hee University Hospital at Gangdong, College of Medicine, Kyung Hee University, Seoul, Republic of Korea

⁵Division of Nephrology, Department of Internal Medicine, College of Medicine, Korea University, Seoul, Republic of Korea

⁶Division of Nephrology and Hypertension, Department of Internal Medicine, Inha University College of Medicine, Incheon, Republic of Korea

⁷Division of Nephrology, Department of Internal Medicine, College of Medicine, Yeungnam University, Daegu, Republic of Korea

⁸Department of Nephrology, Ajou University School of Medicine, Suwon, Republic of Korea

⁹Division of Nephrology, Department of Internal Medicine, Veterans Health Service Medical Center, Seoul, Republic of Korea

†Hyeon Seok Hwang and Jihyun Baek equally contributed as co-first authors.

*Correspondence: Yu Ho Lee

Abstract

Hemodialysis patients are susceptible to cardiovascular remodeling, which increases the risk of cardiovascular morbidity and mortality. Circulating extracellular matrix (ECM)-associated molecules increase during cardiovascular remodeling and can be potential biomarkers of adverse cardiovascular outcomes. However, their clinical significance in patients undergoing hemodialysis remain unclear. This study aimed to elucidate the association between circulating ECM-associated molecules and cardiovascular outcomes in patients undergoing hemodialysis. To this end, we measured levels of plasma matrix metalloproteinase (MMP)-2, MMP-9, tenascin-C, and thrombospondin-2 in 372 patients with hemodialysis. Plasma MMP-2 levels were significantly higher in patients with future cardiovascular events than in those without future cardiovascular events (P = 0.004). All measured molecules had significant correlations with amino-terminal pro-brain natriuretic peptide levels, but the correlation coefficient was the strongest for plasma MMP-2 (rho = 0.317, P < 0.001). High plasma MMP-2 levels were predictive of left ventricular (LV) diastolic dysfunction (adjusted odds ratio per a standard deviation increase = 1.48, 95% confidence interval [CI] = 1.05-2.08) and were independently associated with an increased risk of composite cardiovascular events (adjusted hazard ratio per a standard deviation increase = 1.30, 95% CI = 1.04-1.63). In conclusion, high plasma MMP-2 levels are associated with LV diastolic dysfunction and an increased risk of adverse cardiovascular outcomes in hemodialysis patients.

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형식Correspondence
게재일2024년 02월 (BRIC 등록일 2024-02-14)
연구진국내 연구진
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