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Nano Lett., Feb 07 2024, | https://doi.org/10.1021/acs.nanolett.3c04188 Graphene Hybrid Tough Hydrogels with Nanostructures for Tissue Regeneration

Yonghyun Gwon ^1,2,3ǂ, Sangbae Park^1,2,3,4,5ǂ, Woochan Kim^1,2,3ǂ, Sunho Park^1,2,3,6, Harshita Sharma ^1,2,3, Hoon Eui Jeong ⁷, Hyunjoon Kong⁸, Jangho Kim ^1,2,3,4

¹Department of Convergence Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.

²Department of Rural and Biosystems Engineering, Chonnam National University, Gwangju 61186, Republic of Korea.

³Interdisciplinary Program in IT-Bio Convergence System, Chonnam National University, Gwangju 61186, Republic of Korea.

⁴Institute of Nano-Stem Cells Therapeutics, NANOBIOSYSTEM Co., Ltd, Gwangju 61011, Republic of Korea.

⁵Department of Biosystems Engineering, Seoul National University, Seoul 08826, Republic of Korea.

⁶Department of Bio-Industrial Machinery Engineering, Pusan National University, Miryang 50463, Republic of Korea.

⁷Department of Mechanical Engineering, Ulsan National Institute of Science and Technology (UNIST), Ulsan 44919, Republic of Korea.

⁸Department of Chemical and Biomolecular Engineering, University of Illinois at Urbana-Champaign, Urbana, Illinois 61801, United States.

ǂThese authors contributed equally to this work.

Corresponding Authors : Hoon Eui Jeong, Hyunjoon Kong, Jangho Kim

Abstract

Over the past few decades, hydrogels have attracted considerable attention as promising biomedical materials. However, conventional hydrogels require improved mechanical properties, such as brittleness, which significantly limits their widespread use. Recently, hydrogels with remarkably improved toughness have been developed; however, their low biocompatibility must be addressed. In this study, we developed a tough graphene hybrid hydrogel with nanostructures. The resultant hydrogel exhibited remarkable mechanical properties while representing an aligned nanostructure that resembled the extracellular matrix of soft tissue. Owing to the synergistic effect of the topographical properties, and the enhanced biochemical properties, the graphene hybrid hydrogel had excellent stretchability, resilience, toughness, and biocompatibility. Furthermore, the hydrogel displayed outstanding tissue regeneration capabilities (e.g., skin and tendons). Overall, the proposed graphene hybrid tough hydrogel may provide significant insights into the application of tough hydrogels in tissue regeneration.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-02-14)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오소재

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