한빛사논문
- 조회326
Kyungmin Huh MD, PhD 1,¶, Young-Eun Kim PhD 2,¶, Gi Hwan Bae MPH 3, Jong Youn Moon MD, PhD 4,5, Ji-Man Kang MD, PhD 6,7, Jacob Lee MD, PhD 8, Jang-Whan Bae MD, PhD 9,10, Kyong Ran Peck MD, PhD 1, Jaehun Jung MD, PhD 3,4
1Division of Infectious Diseases, Department of Medicine, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, South Korea
2Department of Bigdata Strategy, National Health Insurance Service, Wonju, South Korea
3Artificial Intelligence and Big-Data Convergence Center, Gil Medical Center, Gachon University College of Medicine, Incheon, South Korea
4Department of Preventive Medicine, Gachon University College of Medicine, Incheon, South Korea
5Center for Public Healthcare, Gachon University Gil Medical Center, Incheon, South Korea
6Department of Pediatrics, Severance Children's Hospital, Yonsei University College of Medicine, Seoul, South Korea
7Institute for Immunology and Immunological Diseases, Yonsei University College of Medicine, Seoul, South Korea
8Division of Infectious Disease, Department of Internal Medicine, Hallym University Kangnam Sacred Heart Hospital, Seoul, South Korea
9Division of Cardiology, Department of Internal Medicine, Chungbuk National University Hospital, Cheongju, South Korea
10Department of Internal Medicine, College of Medicine, Chungbuk National University, Cheongju, South Korea
¶Dr. Huh and Dr. Kim contributed equally to this work as first authors.
Corresponding author : Jaehun Jung MD, PhD
Abstract
Objectives: To assess the association of primary and third doses of vaccination with the risk of post-acute sequelae of COVID-19.
Methods: This retrospective cohort study utilized a combined database of nationwide healthcare claims data, COVID-19 patient registry, and vaccination records from South Korea. Individuals diagnosed with COVID-19 in the Omicron variant-dominant period of January to March 2022 were tracked for 30-120 days post-infection. The exposure of interest was the receipt of primary and third doses of the SARS-CoV-2 vaccine. The occurrence of 26 specific conditions in eight domains was compared using Cox regression with inverse probability of treatment weighting.
Results: This study included 394,773 unvaccinated individuals and 7,604,081 individuals receiving ≥2 doses of vaccine. Compared with unvaccinated individuals, vaccination with at least two doses was associated with a reduced risk (adjusted hazard ratio; 95% confidence interval) of several conditions, including ischemic heart disease (0.73; 0.57-0.94), heart failure (0.55; 0.48-0.63), cardiac dysrhythmia (0.72; 0.61-0.85), cardiac arrest (0.41; 0.33-0.51), pulmonary embolism (0.66; 0.52-0.84), venous thromboembolism (0.54; 0.44-0.66), acute renal failure (0.56; 0.46-0.67), new dialysis (0.45; 0.34-0.59), chronic obstructive pulmonary disease (0.74; 0.65-0.84), acute pancreatitis (0.64; 0.51-0.80), and diabetes (0.82; 0.71-0.95). The risks of heart failure, cardiac dysrhythmias, cardiac arrest, pulmonary embolism, and new dialysis were lower in those vaccinated with three doses compared with two doses.
Conclusions: Vaccination was associated with a decreased risk of post-acute sequelae of COVID-19, suggesting its potential role in mitigating the indirect impacts of COVID-19.
논문정보
- Research article
- 2024년 02월 (BRIC 등록일 2024-02-13)
- 국내 연구진
- 의약학 > 응용의학
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