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고지훈Jihoon Ko

가천대학교

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Adv. Drug Deliv. Rev., Feb 07 2024, S0169-409X(24)00024-3 | https://doi.org/10.1016/j.addr.2024.115202 Revealing the clinical potential of high-resolution organoids

Jihoon Ko ^a,1, Sujin Hyung ^b,c,1, Sunghun Cheong ^d, Yoojin Chung ^e, Noo Li Jeon ^d,f,g,h

^aDepartment of BioNano Technology, Gachon University, Gyeonggi 13120, Republic of Korea

^bPrecision Medicine Research Institute, Samsung Medical Center, Seoul 08826, Republic of Korea

^cDivision of Hematology-Oncology, Department of Medicine, Sungkyunkwan University, Samsung Medical Center, Seoul 08826, Republic of Korea

^dInterdisciplinary Program in Bioengineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

^eDivision of Computer Engineering, Hankuk University of Foreign Studies, Yongin 17035, Republic of Korea

^fDepartment of Mechanical Engineering, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

^gInstitute of Advanced Machines and Design, Seoul National University, 1 Gwanak-ro, Gwanak-gu, Seoul 08826, Republic of Korea

^hQureator, Inc., San Diego, CA, USA

¹These authors contributed equally to this work.

Corresponding author: Noo Li Jeon

Abstract

The symbiotic interplay of organoid technology and advanced imaging strategies yields innovative breakthroughs in research and clinical applications. Organoids, intricate three-dimensional cell cultures derived from pluripotent or adult stem/progenitor cells, have emerged as potent tools for in vitro modeling, reflecting in vivo organs and advancing our grasp of tissue physiology and disease. Concurrently, advanced imaging technologies such as confocal, light-sheet, and two-photon microscopy ignite fresh explorations, uncovering rich organoid information. Combined with advanced imaging technologies and the power of artificial intelligence, organoids provide new insights that bridge experimental models and real-world clinical scenarios. This review explores exemplary research that embodies this technological synergy and how organoids reshape personalized medicine and therapeutics.

논문정보

형식Review Paper
게재일2024년 02월 (BRIC 등록일 2024-02-13)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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