Amal George Kurian (단국대학교) | 한빛사논문 > 한빛사

한빛사논문

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단국대학교

Nano-Micro Lett., Feb 06 2024, 16 (1) 110 | https://doi.org/10.1007/s40820-024-01323-6 Nanozyme-Engineered Hydrogels for Anti-Inflammation and Skin Regeneration

Amal George Kurian^1,2, Rajendra K. Singh^1,2, Varsha Sagar^1,2, Jung-Hwan Lee^1,2,3,4,5,6, Hae-Won Kim^1,2,3,4,5,6

¹Institute of Tissue Regeneration Engineering (ITREN), Dankook University, Cheonan 31116, Republic of Korea

²Department of Nanobiomedical Science & BK21 NBM Global Research Center for Regenerative Medicine, Dankook University, Cheonan 31116, Republic of Korea

³Department of Biomaterials Science, School of Dentistry, Dankook University, Cheonan 31116, Republic of Korea

⁴UCL Eastman-Korea Dental Medicine Innovation Centre, Dankook University, Cheonan 31116, Republic of Korea

⁵Cell and Matter Institute, Dankook University, Cheonan 31116, Republic of Korea

⁶Mechanobiology Dental Medicine Research Center, Dankook University, Cheonan 31116, Republic of Korea

Contact : Hae-Won Kim

Abstract

Inflammatory skin disorders can cause chronic scarring and functional impairments, posing a significant burden on patients and the healthcare system. Conventional therapies, such as corticosteroids and nonsteroidal anti-inflammatory drugs, are limited in efficacy and associated with adverse effects. Recently, nanozyme (NZ)-based hydrogels have shown great promise in addressing these challenges. NZ-based hydrogels possess unique therapeutic abilities by combining the therapeutic benefits of redox nanomaterials with enzymatic activity and the water-retaining capacity of hydrogels. The multifaceted therapeutic effects of these hydrogels include scavenging reactive oxygen species and other inflammatory mediators modulating immune responses toward a pro-regenerative environment and enhancing regenerative potential by triggering cell migration and differentiation. This review highlights the current state of the art in NZ-engineered hydrogels (NZ@hydrogels) for anti-inflammatory and skin regeneration applications. It also discusses the underlying chemo-mechano-biological mechanisms behind their effectiveness. Additionally, the challenges and future directions in this ground, particularly their clinical translation, are addressed. The insights provided in this review can aid in the design and engineering of novel NZ-based hydrogels, offering new possibilities for targeted and personalized skin-care therapies.

논문정보

형식Review Paper
게재일2024년 02월 (BRIC 등록일 2024-02-15)
연구진국내 연구진
분야 의약학 > 재생의학

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