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J. Hazard. Mater., Sep 15 2022, 438 S0304-3894(22)01264-X | https://doi.org/10.1016/j.jhazmat.2022.129471 Biokinetics of fluorophore-conjugated polystyrene microplastics in marine mussels

Yunwi Heo ^a,b,1, Wan-Seob Cho ^c,1, Muthuchamy Maruthupandy ^c, Seung-Kyu Kim ^d,e, June-Woo Park ^a,f

^aEnvironmental Exposure & Toxicology Research Center, Korea Institute of Toxicology, 17 Jegok-gil, Jinju 52834, Republic of Korea

^bDepartment of Pharmacology and Toxicology, College of Veterinary Medicine, Gyeongsang National University, 501, Jinju-daero, Jinju 52828, Republic of Korea

^cLab of Toxicology, Department of Health Sciences, The Graduate School of Dong-A University, 37, Nakdong-daero 550 beon-gil, Saha-gu, Busan 49315, Republic of Korea

^dDepartment of Marine Science, College of Natural Sciences, Incheon National University, Academy-ro 119, Yeounsu-gu, Incheon 22012, Republic of Korea

^eResearch Institute of Basic Sciences, Incheon National University, Academy-ro 119, Yeounsu-gu, Incheon 22012, Republic of Korea

^fHuman and Environmental Toxicology Program, Korea University of Science and Technology (UST), 217, Gajeong-ro, Daejeon 34113, Republic of Korea

¹Yunwi Heo and Wan-Seob Cho equally contributed to this work.

Corresponding author : June-Woo Park

Abstract

Biokinetic information on microplastics in bivalves is required to reduce the human exposure, but little is known about the time-course and size effect on tissue absorption and clearance. The biokinetics of fluorophore-labeled polystyrene microbeads with diameters 10 µm (PL10) and 90 µm (PL90) in Mytilus galloprovincialis marine mussels was investigated in the present study. It was found that both PL10 and PL90 showed a biphasic tissue distribution pattern in digestive and non-digestive tissues, highlighting the significant tissue distribution starting from 48 h post-treatment. The differential size effect on tissue distribution was observed only in the gills, which suggests that PL10 accumulates more than PL90. The depuration kinetics show that particles of both sizes can be cleared in any tissue, but non-digestive tissue requires a longer duration for depuration than digestive tissue. The differential size effect on depuration was observed for both digestive and non-digestive tissues, suggesting that PL10 needed a longer duration for depuration than PL90. More than seven days were needed for depuration of microplastics in mussels, which is an exceptionally longer period compared to conventional depuration of bivalves. The most significant improvement of this study is providing the biokinetics of two different-sized microplastics in mussels and the differential time for purging microplastics from mussels.

논문정보

형식Research article
게재일2022년 09월 (BRIC 등록일 2024-02-13)
연구진국내 연구진
분야 바이오·의료융합 > 다학제 융합/복합

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