한빛사논문
- 조회317
인하대학교
Muthuchamy Maruthupandy a,1, Muruganantham Rethinasabapathy b,1, Soyeon Jeon a, Jiyoung Jeong a, Eunsu Kim b, Sinuk Lee a, Songyeon Kim a, Gyuri Kim a, Yeonjeong Ha a, Eunsol Bae a, Yun Suk Huh b, Wan-Seob Cho a
aDepartment of Health Sciences, The Graduate School of Dong-A University, 37, Nakdong-daero, 550 beon-gil, Busan 49315, Republic of Korea
bDepartment of Biological Sciences and Bioengineering, NanoBio High-Tech Materials Research Center, Inha University, 100, Inharo, Nam-gu, Incheon 22212, Republic of Korea
1MM and MR equally contributed to this work.
Corresponding authors : Yun Suk Huh, Wan-Seob Cho
Abstract
Two-dimensional (2D) materials, such as MXenes and graphene, are tested as catalysts, sensors, and nanomedicine, but their safety and biocompatibility are poorly understood. In this study, Ti3C2 MXenes (single-layer and multilayer) and graphene oxide are prepared to evaluate their inflammatory potential in vivo and in vitro using the read-across approach. Pulmonary exposure of the test materials in mice led to significant dose-dependent increases in several toxicity endpoints of bronchoalveolar lavage fluid. The correlation of the oxidative potential of the test materials and the toxicity endpoints shows that both the intrinsic and intracellular oxidative potentials of 2D materials are key factors for the inflammation and damage of the plasma membrane. Scanning electron microscopy and in vitro studies using the differentiated THP-1 macrophage-like cells support this finding. Furthermore, the toxicity of test items is reduced when treated with N-acetyl cysteine, a scavenger for reactive oxygen species; this finding further supports the oxidative stress paradigm proposed in this study. This oxidative stress paradigm may apply to 2D materials in general and improve the understanding the toxicity mechanism of such materials, which would facilitate the design of safer functional 2D materials.
논문정보
- Research article
- 2023년 08월 (BRIC 등록일 2024-02-13)
- 국내 연구진
- 바이오·의료융합 > 다학제 융합/복합
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