박장웅 (연세대학교) | 한빛사논문 > 한빛사

한빛사논문

조회239

연세대학교

CV File 73 kb

Sci. Adv., Feb 09 2024, 10 (6) | https://doi.org/10.1126/sciadv.adk7805 Real-time in vivo monitoring of intraocular pressure distribution in the anterior chamber and vitreous chamber for diagnosis of glaucoma

Hunkyu Seo^{1 2 †}, Yeon-Mi Hong ^{1 2 †}, Won Gi Chung ^{1 2}, Wonjung Park ^{1 2}, Jakyoung Lee ^{1 2}, Hong Kyun Kim ³, Suk Ho Byeon ⁴, Dai Woo Kim^{3 *}, Jang-Ung Park ^{1 2 5 6 *}

¹Department of Materials Science and Engineering, Yonsei University College of Engineering, Seoul 03722, Republic of Korea.

²Center for Nanomedicine, Institute for Basic Science (IBS), Yonsei University, Seoul 03722, Republic of Korea.

³Department of Ophthalmology, Kyungpook National University School of Medicine, Daegu 41944, Republic of Korea.

⁴Department of Ophthalmology, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

⁵Department of Neurosurgery, Yonsei University College of Medicine, Seoul 03722, Republic of Korea.

⁶Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul 03722, Republic of Korea.

^†These authors contributed equally
^*Corresponding authors: correspondence to Dai Woo Kim or Jang-Ung Park

Abstract

Glaucoma causes irreversible vision loss due to optic nerve damage and retinal cell degeneration. Since high intraocular pressure (IOP) is a major risk factor for glaucoma development, accurate IOP measurement is crucial, especially intravitreal IOP affecting the optical nerve and cells. However, conventional methods have limits in selectively and directly detecting local retina pressure. Here, we present continuous measurements of local IOP values in the anterior chamber and vitreous chamber of living animals using minimally invasive probes with pressure-sensitive transistors. After inducing glaucoma in animal models, we compared the local IOP distribution between normal and glaucomatous eyes. We also compared IOP values detected in the cornea using tonometry measurements. Our findings revealed that glaucoma induced higher IOP in the vitreous chamber than in the anterior chamber, indicating that measuring IOP in the vitreous chamber is key to the glaucoma model. This progress offers future directions for diagnosis and treatment of glaucoma.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-02-29)
연구진국내 연구진
분야 바이오·의료융합 > 바이오·의료융합 기타

댓글 작성 로그인

CV 열람하기

연락처 보기