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Med. Res. Rev., Feb 02 2024, | https://doi.org/10.1002/med.22022
Natural products as IL-6 inhibitors for inflammatory diseases: Synthetic and SAR perspective
Dipesh S Harmalkar 1,2,3, Aneesh Sivaraman 1,2, Hossam Nada 1, Joohan Lee 1, Hyeseul Kang 1, Yongseok Choi 2, Kyeong Lee 1
1BK21 FOUR Team and Integrated Research Institute for Drug Development, College of Pharmacy, Dongguk University-Seoul, Goyang, South Korea.
2Department of Biotechnology, College of Life Sciences and Biotechnology, Korea University, Seoul, South Korea.
3Department of Chemistry, Government College of Arts, Science & Commerce, Sanquelim, Goa, India.
Correspondences : Yongseok Choi, Kyeong Lee
Abstract
Interleukin-6 (IL-6), a pleiotropic cytokine, plays a pivotal role in the pathophysiology of various diseases including diabetes, atherosclerosis, Alzheimer's disease, multiple myeloma, rheumatoid arthritis, and prostate cancer. The signaling pathways associated with IL-6 offer promising targets for therapeutic interventions in inflammatory diseases and IL-6-dependent tumors. Although certain anti-IL-6 monoclonal antibodies are currently employed clinically, their usage is hampered by drawbacks such as high cost and potential immunogenicity, limiting their application. Thus, the imperative arises to develop novel small non-peptide molecules acting as IL-6 inhibitors. Various natural products derived from diverse sources have been investigated for their potential to inhibit IL-6 activity. Nevertheless, these natural products remain inadequately explored in terms of their structure-activity relationships. In response, our review aims to provide syntheses and structure activity perspective of natural IL-6 inhibitors. The comprehensive amalgamation of information presented in this review holds the potential to serve as a foundation for forthcoming research endeavors by medicinal chemists, facilitating the design of innovative IL-6 inhibitors to address the complexities of inflammatory diseases.
논문정보
- Review Paper
- 2024년 02월 (BRIC 등록일 2024-02-15)
- 국내(교신)+국외 연구진
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