이원지 (건국대학교, 현 성균관대학교)

상위피인용논문

조회261

이원지Won Ji Lee

건국대학교, 현 성균관대학교

J. Clin. Med., 2020 Mar 31;9(4):966 | https://doi.org/10.3390/jcm9040966 Genetic and epigenetic etiology underlying autism spectrum disorder

Sang Hoon Yoon ^{1 †}, Joonhyuk Choi ^{1 †}, Won Ji Lee ^{1 †}, Jeong Tae Do ^{1 *}

¹Department of Stem Cell and Regenerative Biotechnology, KU Institute of Technology, Konkuk University, Seoul 05029, Korea.

^†Authors with equal contribution.
^*Corresponding author: correspondence to Jeong Tae Do

Abstract

Autism spectrum disorder (ASD) is a pervasive neurodevelopmental disorder characterized by difficulties in social interaction, language development delays, repeated body movements, and markedly deteriorated activities and interests. Environmental factors, such as viral infection, parental age, and zinc deficiency, can be plausible contributors to ASD susceptibility. As ASD is highly heritable, genetic risk factors involved in neurodevelopment, neural communication, and social interaction provide important clues in explaining the etiology of ASD. Accumulated evidence also shows an important role of epigenetic factors, such as DNA methylation, histone modification, and noncoding RNA, in ASD etiology. In this review, we compiled the research published to date and described the genetic and epigenetic epidemiology together with environmental risk factors underlying the etiology of the different phenotypes of ASD.

논문정보

형식Review Paper
게재일2020년 05월 (BRIC 등록일 2024-02-05)
연구진국내 연구진
분야 생명과학 > 유전학
피인용횟수120회 이상 인용된 논문

댓글 작성 로그인

CV 열람하기

연락처 보기