정유진 (인천대학교)

한빛사논문

조회352

정유진Yujin Jeong

인천대학교

Adv. Funct. Mater., Volume33, Issue51 Dec 15, 2023 2305680 | https://doi.org/10.1002/adfm.202305680 Liquid Metal Electrodynamic Accumulation Microfluidics System for DNA Memory and Liquid Biopsy

Yujin Jeong¹, Seunghwan Noh^1,2, Minsang Yu¹, Sung-pil Chang³, Hyuksoo Eun^4,5, Jinchul Kim⁶, Youngjun Song^1,7

¹Department of Nano-Bioengineering, Incheon, Incheon National University 119 Academy-ro, Incheon, 22012 Republic of Korea

²Department of Bioengineering, Northeastern University, Boston, MA, 02115 USA

³Department of Electronic Engineering, Incheon at Inha University, 100 Inharo, Nam-gu, 22212 Republic of Korea

⁴Department of Internal Medicine, School of Medicine, Chungnam National University, 266, Munhwa-ro, Jung-gu, Daejeon, 35015 Republic of Korea

⁵Department of Gastroenterology, Chungnam National University Hospital, 282, Munhwa-ro, Jung-gu, Daejeon, 35015 Republic of Korea

⁶Ageing Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, 34141 Republic of Korea

⁷Standard Bioelectronics Co., 511 Michuhol Tower Hall Tower Gaetbeol-ro 12, Incheon, 21999 Republic of Korea

Y.J. and S.N. contributed equally to this work.

CORRESPONDING AUTHORS : Hyuksoo Eun, Jinchul Kim, Youngjun Song

Abstract

This study presents a liquid metal electrodynamic accumulation microfluidic (LEAM) device that effectively controls DNA dynamics using liquid metal (LM) electrodes and an applied electric field. The characteristics of LM in LEAM include electrochemical attack, and LM properties and behavior at high voltages. The findings demonstrate the ability of the LEAM system to control DNA dynamics and thermodynamics. Short-sequence single stranded DNA (ssDNA) hybridization and displacement are performed using an exchange buffer solution. By scaling up the LEAM system for a droplet-based approach, discrete manipulation of DNA samples is achieved. A three-bit molecular ssDNA memory system using a molecular beacon system is demonstrated, and its application is extended as a diagnostic tool for detecting gene molecules such as micro-RNA. This study highlights the potential of the LEAM system for use in various biomedical and biotechnological applications, owing to its effective handling of biomolecules.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2024-02-05)
연구진국내(교신)+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

댓글 작성 로그인

CV 열람하기

연락처 보기