Shivani Devi (가천대학교) | 한빛사논문 > 한빛사

한빛사논문

조회381

가천대학교

Gut Microbes, 01 Feb 2024 | https://doi.org/10.1080/19490976.2024.2307568 Gut microbiota-derived indole compounds attenuate metabolic dysfunction-associated steatotic liver disease by improving fat metabolism and inflammation

Byeong Hyun Min^a*, Shivani Devi^b*, Goo Hyun Kwon^a*, Haripriya Gupta^a, Jin-Ju Jeong^a, Satya Priya Sharma^a, Sung-Min Won^a, Ki-Kwang Oh^a, Sang Jun Yoon^a, Hee Jin Park^a, Jung A Eom^a, Min Kyo Jeong^a, Ji Ye Hyun^a, Nattan Stalin^b, Tae-Sik Park^b, Jieun Choi^c, Do Yup Lee^c, Sang Hak Han^d, Dong Joon Kim^a, and Ki Tae Suk^a

^aInstitute for Liver and Digestive Diseases, Hallym University, Chuncheon, Republic of Korea;

^bDepartment of Life Science, Gachon University, Sungnam, Republic of Korea;

^cDepartment of Agricultural Biotechnology, Center for Food and Bioconvergence, Research Institute of Agricultural and Life Sciences, Seoul National University, Seoul, Republic of Korea;

^dDepartment of Pathology, Hallym University College of Medicine, Chuncheon, Republic of Korea

^*These authors equally contributed.

CONTACT: Ki Tae Suk

Abstract

Metabolic dysfunction-associated steatotic liver disease (MASLD) is the most common chronic liver disease, and its prevalence has increased worldwide in recent years. Additionally, there is a close relationship between MASLD and gut microbiota-derived metabolites. However, the mechanisms of MASLD and its metabolites are still unclear. We demonstrated decreased indole-3-propionic acid (IPA) and indole-3-acetic acid (IAA) in the feces of patients with hepatic steatosis compared to healthy controls. Here, IPA and IAA administration ameliorated hepatic steatosis and inflammation in an animal model of WD-induced MASLD by suppressing the NF-κB signaling pathway through a reduction in endotoxin levels and inactivation of macrophages. Bifidobacterium bifidum metabolizes tryptophan to produce IAA, and B. bifidum effectively prevents hepatic steatosis and inflammation through the production of IAA. Our study demonstrates that IPA and IAA derived from the gut microbiota have novel preventive or therapeutic potential for MASLD treatment.

논문정보

형식Research article
게재일2024년 02월 (BRIC 등록일 2024-02-02)
연구진국내 연구진
분야 의약학 > 응용의학

댓글 작성 로그인

CV 열람하기

연락처 보기