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Mol. Cancer, Jan 30 2024, 23 (1) | https://doi.org/10.1186/s12943-024-01941-z Mapping cancer biology in space: applications and perspectives on spatial omics for oncology

Sumin Lee^1,2†, Gyeongjun Kim^3†, JinYoung Lee⁴, Amos C. Lee^2,5*† and Sunghoon Kwon^{1,3,5,6,7*†}

¹Department of Electrical and Computer Engineering, Seoul National University, Seoul 08826, Republic of Korea

²Meteor Biotech,, Co. Ltd, Seoul 08826, Republic of Korea

³Interdisciplinary Program in Bioengineering, Seoul National University, Seoul 08826, Republic of Korea

⁴Division of Engineering Science, University of Toronto, Toronto, Ontario, ON M5S 3H6, Canada

⁵Bio-MAX Institute, Seoul National University, Seoul 08826, Republic of Korea

⁶Institutes of Entrepreneurial BioConvergence, Seoul National University, Seoul 08826, Republic of Korea

⁷Cancer Research Institute, Seoul National University College of Medicine, Seoul 03080, Republic of Korea

^†Sumin Lee, Gyeongjun Kim, Amos C. Lee and Sunghoon Kwon contributed equally to this work.

^*Correspondence: Amos C. Lee, Sunghoon Kwon

Abstract

Technologies to decipher cellular biology, such as bulk sequencing technologies and single-cell sequencing technologies, have greatly assisted novel findings in tumor biology. Recent findings in tumor biology suggest that tumors construct architectures that influence the underlying cancerous mechanisms. Increasing research has reported novel techniques to map the tissue in a spatial context or targeted sampling-based characterization and has introduced such technologies to solve oncology regarding tumor heterogeneity, tumor microenvironment, and spatially located biomarkers. In this study, we address spatial technologies that can delineate the omics profile in a spatial context, novel findings discovered via spatial technologies in oncology, and suggest perspectives regarding therapeutic approaches and further technological developments.

논문정보

형식Review Paper
게재일2024년 01월 (BRIC 등록일 2024-02-01)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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