최형수 (University of Illinois at Urbana-Champaign) | 한빛사논문 > 한빛사

한빛사논문

조회236

University of Illinois at Urbana-Champaign

Nano Lett., Jan 26 2024, | https://doi.org/10.1021/acs.nanolett.3c04352 Chenodeoxycholic Acid-Loaded Nanoparticles Are Sufficient to Decrease Adipocyte Size by Inducing Mitochondrial Function

Weinan Zhou ¹, Benjamin Lew ², Hyungsoo Choi ², Kyekyoon Kim^2,3,4, Sayeepriyadarshini Anakk ^1,4,5,6

¹Department of Molecular and Integrative Physiology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

²Department of Electrical and Computer Engineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

³Department of Bioengineering, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

⁴Beckman Institute for Advanced Science and Technology, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

⁵Division of Nutritional Sciences, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

⁶Cancer Center at Illinois, University of Illinois Urbana-Champaign, Urbana, Illinois 61801, United States.

W.Z. and B.L. contributed equally to this work.

Corresponding Authors : Hyungsoo Choi, Kyekyoon Kim, Sayeepriyadarshini Anakk

Abstract

Excess fat accumulation is not only associated with metabolic diseases but also negatively impacts physical appearance and emotional well-being. Bile acid, the body's natural emulsifier, is one of the few FDA-approved noninvasive therapeutic options for double chin (submental fat) reduction. Synthetic sodium deoxycholic acid (NaDCA) causes adipose cell lysis; however, its side effects include inflammation, bruising, and necrosis. Therefore, we investigated if an endogenous bile acid, chenodeoxycholic acid (CDCA), a well-known signaling molecule, can be beneficial without many of the untoward effects. We first generated CDCA-loaded nanoparticles to achieve sustained and localized delivery. Then, we injected them into the subcutaneous fat depot and monitored adipocyte size and mitochondrial function. Unlike NaDCA, CDCA did not cause cytolysis. Instead, we demonstrate that a single injection of CDCA-loaded nanoparticles into the subcutaneous fat reduced the adipocyte size by promoting fat burning and mitochondrial respiration, highlighting their potential for submental fat reduction.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-02-19)
연구진국외 연구진
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