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Stevens Institute of Technology

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Adv. Healthc. Mater., Jan 27 2024, | https://doi.org/10.1002/adhm.202303026 Lung-Mimetic Hydrofoam Sealant to Treat Pulmonary Air Leak

Meghan R Pinezich ¹, Mohammad Mir ², Pamela L Graney ¹, Daniel Naveed Tavakol ¹, Jiawen Chen ², Maria Hudock ¹, Olimpia Gavaudan ¹, Panpan Chen ^1,3, Sarah R Kaslow ^1,3, Jonathan A Reimer^1,3, Julie Van Hassel ^1,3, Brandon A Guenthart ⁴, John D O'Neill ⁵, Matthew Bacchetta ^6,7, Jinho Kim ², Gordana Vunjak-Novakovic ^1,8

¹Columbia University, Department of Biomedical Engineering, USA.

²Stevens Institute of Technology, Department of Biomedical Engineering, USA.

³Columbia University Irving Medical Center, Department of Surgery, USA.

⁴Stanford University, Department of Cardiothoracic Surgery, USA.

⁵State University of New York Downstate Medical Center, Department of Cell Biology, USA.

⁶Vanderbilt University Medical Center, Department of Thoracic Surgery, Vanderbilt University, USA.

⁷Vanderbilt University, Department of Biomedical Engineering, Vanderbilt University, USA.

⁸Columbia University Irving Medical Center, Department of Medicine, Vanderbilt University, USA.

CORRESPONDING AUTHORS: Jinho Kim, Gordana Vunjak-Novakovic

Abstract

Pulmonary air leak is the most common complication of lung surgery, contributing to post-operative morbidity in up to 60% of patients, yet there is no reliable treatment. Available surgical sealants do not match the demanding deformation mechanics of lung tissue and therefore fail to seal air leak. To address this therapeutic gap, we developed and systematically evaluated a sealant with structural and mechanical similarity to subpleural lung. Our "lung-mimetic" sealant is a hydrofoam material that has alveolar-like porous ultrastructure, lung-like viscoelastic properties (adhesive, compressive, tensile), and lung extracellular matrix-derived signals (matrikines) to support tissue repair. In biocompatibility testing, the lung-mimetic sealant showed minimal cytotoxicity and immunogenicity in vitro. Human primary monocytes exposed to sealant matrikines in vitro upregulated key genes (MARCO, PDGFB, VEGF) known to correlate with pleural wound healing and tissue repair in vivo. In rat and swine models of pulmonary air leak, our lung-mimetic sealant rapidly sealed air leak and restored baseline lung mechanics. Altogether, these data indicate that our lung-mimetic sealant can effectively seal pulmonary air leak and promote a favorable cellular response in vitro. This article is protected by copyright. All rights reserved.

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형식Research article
게재일2024년 01월 (BRIC 등록일 2024-02-19)
연구진국외 연구진
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