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University of California, Los Angeles

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Adv. Healthc. Mater., Jan 26 2024, | https://doi.org/10.1002/adhm.202303592 Self-assembled Nanocomposite Hydrogels as Carriers for Demineralized Bone Matrix Particles and Enhanced Bone Repair

Chen Chen ¹, Zhi Li ¹, Changlu Xu ¹, Minjee Kang ¹, Chung-Sung Lee ^1,2, Tara Aghaloo ³, Min Lee^1,4

¹Division of Oral and Systemic Health Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.

²Department of Pharmaceutical Engineering, Soonchunhyang University, Asan, 31538, Republic of Korea.

³Division of Diagnostic and Surgical Sciences, School of Dentistry, University of California, Los Angeles, CA, 90095, USA.

⁴Department of Bioengineering, University of California, Los Angeles, CA, 90095, USA.

CORRESPONDING AUTHORS: Tara Aghaloo, Min Lee

Abstract

Demineralized bone matrix (DBM) has been widely used as an allogeneic alternative to autologous bone graft for bone repair. However, more extensive use of DBM is limited due to its particulate nature after demineralization and rapid particle dispersion following irrigation, resulting in unpredictable osteoinductivity. Here, we report a new design of injectable hydrogel carriers for DBM that combine self-healing ability and osteogenic properties based on the self-assembly of guanidinylated hyaluronic acid and silica-rich nanoclays. The nanoclays serve as reversible linkages to form a dynamic hydrogel network with the guanidine moieties on the polymer chains. Gelation kinetics and mechanical properties can be controlled by altering nanoclay content in the hydrogel. The resulting hydrogel exerts self-healing ability due to its dynamic crosslinks and well retains its overall performance with high DBM loading. The hydrogel exhibits great cytocompatibility and osteogenic effects mediated by the nanoclays. In vivo delivery of DBM using the nanocomposite hydrogel further demonstrates robust bone regeneration in a mouse calvarial defect model in comparison to DBM delivered with aqueous HA. This work suggests a promising hydrogel platform for many applications including therapeutic delivery and tissue engineering. This article is protected by copyright. All rights reserved.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-30)
연구진국내+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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