배채원 (서울대학교)

한빛사논문

조회468

배채원Chaewon Bae

서울대학교

Small, Jan 26 2024, | https://doi.org/10.1002/smll.202310873 Synergistic Effect of Ferroptosis-Inducing Nanoparticles and X-Ray Irradiation Combination Therapy

Chaewon Bae ¹, Rodrigo Hernández Millares ², Suhyun Ryu ³, Hyowon Moon ⁴, Dongwoo Kim ³, Gyubok Lee ³, Zhuomin Jiang ³, Min Hee Park ⁵, Kyung Hwan Kim⁴, Woong Sub Koom ⁴, Sung-Joon Ye^3,6,7,8, Kangwon Lee ^3,8

¹Program in Nanoscience and Technology, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.

²Program in Biomedical Radiation Sciences, Department of Transdisciplinary Studies, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.

³Department of Applied Bioengineering, Graduate School of Convergence Science and Technology, Seoul National University, Seoul, 08826, Republic of Korea.

⁴Department of Radiation Oncology, Yonsei Cancer Center, Heavy Ion Therapy Research Institute, Yonsei University College of Medicine, Seoul, 03722, Republic of Korea.

⁵THEDONEE, 1208, 156, Gwanggyo-ro, Yeongtong-gu, Suwon-si, Gyeonggi-do, 16506, Republic of Korea.

⁶Biomedical Research Institute, Seoul National University Hospital, Seoul, 03080, South Korea.

⁷Advanced Institute of Convergence Technology, Seoul National University, Suwon, 16229, South Korea.

⁸Research Institute for Convergence Science, Seoul National University, Seoul, 08826, Republic of Korea.

C.B. and R.H.M. contributed equally to this work.

CORRESPONDING AUTHORS: Woong Sub Koom, Sung-Joon Ye, Kangwon Lee

Abstract

Ferroptosis, characterized by the induction of cell death via lipid peroxidation, has been actively studied over the last few years and has shown the potential to improve the efficacy of cancer nanomedicine in an iron-dependent manner. Radiation therapy, a common treatment method, has limitations as a stand-alone treatment due to radiation resistance and safety as it affects even normal tissues. Although ferroptosis-inducing drugs help alleviate radiation resistance, there are no safe ferroptosis-inducing drugs that can be considered for clinical application and are still in the research stage. Here, the effectiveness of combined treatment with radiotherapy with Fe and hyaluronic acid-based nanoparticles (FHA-NPs) to directly induce ferroptosis, considering the clinical applications is reported. Through the induction of ferroptosis by FHA-NPs and apoptosis by X-ray irradiation, the therapeutic efficiency of cancer is greatly improved both in vitro and in vivo. In addition, Monte Carlo simulations are performed to assess the physical interactions of the X-rays with the iron-oxide nanoparticle. The study provides a deeper understanding of the synergistic effect of ferroptosis and X-ray irradiation combination therapy. Furthermore, the study can serve as a valuable reference for elucidating the role and mechanisms of ferroptosis in radiation therapy.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-29)
연구진국내 연구진
분야 바이오·의료융합 > 바이오소재

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