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J. Hazard. Mater., Jan 11 2024, 466 S0304-3894(24)00075-X | https://doi.org/10.1016/j.jhazmat.2024.133497
Avoiding cantharidin through ionotropic receptors
Roshani Nhuchhen Pradhan, Bhanu Shrestha, Youngseok Lee
Department of Bio & Fermentation Convergence Technology, Kookmin University, Seoul 02707, Republic of Korea
Corresponding author : Youngseok Lee
Abstract
The discernment and aversion of noxious gustatory stimuli profoundly influence homeostasis maintenance and survival of fauna. Cantharidin, a purported aphrodisiac, is a monoterpenoid compound secreted by many species of blister beetle, particularly by the Spanish fly, Lytta vesicatoria. Although the various advantageous functions of cantharidin have been described, its taste analysis and toxic properties in animalshave been rarely explored. Our study using Drosophila melanogaster examines the taste properties of cantharidin along with its potential hazardous effect in the internal organs of animals. Here, we find that cantharidin activates bitter taste receptors. Our findings show that specific ionotropic receptors (IR7g, IR51b, and IR94f) in labellar bitter-sensing neurons, along with co-receptors IR25a and IR76b, are responsible for detecting cantharidin. By introducing the IR7g and IR51b in sweet and bitter neurons, naturally expressing IR76b and IR25a, we show that these genes are sufficient for cantharidin perception. Moreover, we witness the deleterious ramifications of cantharidin on survival and visceral integrities, shedding light on its hazardous effect.
논문정보
- Research article
- 2024년 01월 (BRIC 등록일 2024-01-29)
- 국내 연구진
- 생명과학 > 신경생물학
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