최명은 (울산대학교 의과대학, 서울아산병원)

한빛사논문

조회165

최명은Myoung Eun Choi

울산대학교 의과대학, 서울아산병원

J. Am. Acad. Dermatol., Jan 23 2024, S0190-9622(24)00103-8 | https://doi.org/10.1016/j.jaad.2023.12.064 Baseline Serum Neutrophil-to-Lymphocyte Ratio in Acral Melanoma Compared to Non-Acral Melanoma and its Prognostic Significance

Myoung Eun Choi MD PhD^∗, Joon Min Jung MD PhD^∗, Do Hyung Kim MD, Chong Hyun Won MD PhD, Sung Eun Chang MD PhD, Mi Woo Lee MD PhD, Woo Jin Lee MD PhD

Department of Dermatology, Asan Medical Center, University of Ulsan College of Medicine, 88 Olympic-ro 43-gil, Songpa-gu, Seoul 05505, Republic of Korea

^∗These authors contributed equally as first authors

Corresponding author: Woo Jin Lee, MD, PhD

Abstract

Acral lentiginous melanoma (ALM), a cutaneous melanoma subtype, exhibits a poorer prognosis than non-acral cutaneous melanoma (NACM). The neutrophil-to-lymphocyte ratio (NLR) is emerging as a prognostic indicator across diverse cancers. We explored the baseline NLR disparities between ALM and NACM, and the NLR's prognostic significance in patients with ALM. We reviewed records of patients with ALM and NACM diagnosed between 1997 and 2022, analyzing medical data. Among 327 and 159 patients with ALM and NACM, respectively, baseline NLR varied based on distinct clinicopathological factors between ALM and NACM. In stage 3-4 melanomas, the median NLR for ALM (2.18; interquartile range, 1.70-3.08) significantly surpassed NACM (1.74; interquartile range, 1.33-2.53) (P=0.029). In patients with ALM, high NLR (hazard ratio, 1.64; 95% confidence interval, 1.02-2.66; P=0.043) was independently correlated with poor progression-free survival when adjusting for ulceration, Breslow thickness ≥2 mm, and nodal invasion. Single-center, retrospective design. Advanced-stage ALM exhibited a significantly higher baseline NLR compared to that of NACM. Evaluating baseline NLR could provide valuable prognostic insights for patients with ALM.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-02-16)
연구진국내 연구진
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