한빛사논문
- 조회399
Min Seong Kim 1,2, Hyesoo Kim 1,2, Gabsang Lee 1,2,3
1Institute for Cell Engineering, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
2Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
3The Solomon Snyder Department of Neuroscience, Johns Hopkins University School of Medicine, Baltimore, MD, USA.
CORRESPONDING AUTHOR : Gabsang Lee
Abstract
Parkinson's Disease (PD) is one of the most devastating neurological diseases, however there is no effective cure yet. The availability of human induced pluripotent stem cells (iPSCs) provides unprecedented opportunities to understand the pathogenic mechanism and identification of new therapy for PD. In this review, we will introduce new model system of PD, including two-dimensional (2D) human iPSC-derived midbrain dopaminergic (mDA) neurons, 3D iPSC-derived midbrain organoids (MOs) with cellular complexity, and more advanced microphysiological systems (MPS) with three-dimensional (3D) organoids. We believe that successful integrations and applications of iPSC, organoid, and MPS technologies can bring new insight on PD's pathogenesis that will lead to more effective treatments for this debilitating disease.
논문정보
- Review Paper
- 2024년 01월 (BRIC 등록일 2024-01-29)
- 국외 연구진
- 의약학 > 재생의학
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