이동욱 (한국생산기술연구원)

한빛사논문

조회381

한국생산기술연구원

CV File 146 kb

Bioact. Mater., 2023 Dec 19:34:112-124 | https://doi.org/10.1016/j.bioactmat.2023.12.009 Antibiofilm and antithrombotic hydrogel coating based on superhydrophilic zwitterionic carboxymethyl chitosan for blood-contacting devices

Dong Uk Lee^a, Mukhammad Kayumov ^b, Junghun Park ^a, Se Kye Park ^a, Yeongkwon Kang ^c, Yejin Ahn ^d, Woojin Kim ^a, Seung Hwa Yoo ^e, Jun-Kyu Park ^f, Bong-Gi Kim ^d, Yong Suk Oh ^g, In-Seok Jeong ^b, Dong Yun Choi ^a

^aBiomedical Manufacturing Technology Center, Korea Institute of Industrial Technology, Yeongcheon, 38822, Republic of Korea

^bDepartment of Thoracic and Cardiovascular Surgery, Chonnam National University Hospital and Medical School, Gwangju, 61469, Republic of Korea

^cResearch Institute of Advanced Materials, Seoul National University, Seoul, 08826, Republic of Korea

^dDepartment of Organic and Nano System Engineering, Konkuk University, Seoul, 05029, Republic of Korea

^eDepartment of Quantum System Engineering, Jeonbuk National University, Jeonju-si, 54896, Republic of Korea

^fIMT Inc., Gwangju, 61086, Republic of Korea

^gDepartment of Mechanical Engineering, Changwon National University, Changwon, 51140, Republic of Korea

Corresponding authors: In-Seok Jeong, Dong Yun Choi

Abstract

Blood-contacting devices must be designed to minimize the risk of bloodstream-associated infections, thrombosis, and intimal lesions caused by surface friction. However, achieving effective prevention of both bloodstream-associated infections and thrombosis poses a challenge due to the conflicting nature of antibacterial and antithrombotic activities, specifically regarding electrostatic interactions. This study introduced a novel biocompatible hydrogel of sodium alginate and zwitterionic carboxymethyl chitosan (ZW@CMC) with antibacterial and antithrombotic activities for use in catheters. The ZW@CMC hydrogel demonstrates a superhydrophilic surface and good hygroscopic properties, which facilitate the formation of a stable hydration layer with low friction. The zwitterionic-functionalized CMC incorporates an additional negative sulfone group and increased negative charge density in the carboxyl group. This augmentation enhances electrostatic repulsion and facilitates the formation of hydration layer. This leads to exceptional prevention of blood clotting factor adhesion and inhibition of biofilm formation. Subsequently, the ZW@CMC hydrogel exhibited biocompatibility with tests of in vitro cytotoxicity, hemolysis, and catheter friction. Furthermore, in vivo tests of antithrombotic and systemic inflammation models with catheterization indicated that ZW@CMC has significant advantages for practical applications in cardiovascular-related and sepsis treatment. This study opens a new avenue for the development of chitosan-based multifunctional hydrogel for applications in blood-contacting devices.

논문정보

형식Research article
게재일2023년 12월 (BRIC 등록일 2024-01-24)
연구진국내 연구진
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