Thi-Kem Nguyen (영남대학교)

한빛사논문

조회257

Thi-Kem NguyenThi-Kem Nguyen

영남대학교

Acta Pharm. Sin. B, Volume 14, Issue 1, January 2024, Pages 273-291 | https://doi.org/10.1016/j.apsb.2023.10.019 Adiponectin restores the obesity-induced impaired immunomodulatory function of mesenchymal stromal cells via glycolytic reprogramming

Duc-Vinh Pham ^a,b,†, Thi-Kem Nguyen ^b,†, Bao-Loc Nguyen ^b, Jong-Oh Kim ^b, Jee-Heon Jeong ^e, Inho Choi ^c,d, Pil-Hoon Park ^b,d

^aDepartment of Pharmacology, Hanoi University of Pharmacy, Hanoi 100000, Viet Nam

^bCollege of Pharmacy, Yeungnam University, Gyeongsan 38541, Republic of Korea

^cDepartment of Medical Biotechnology, Yeungnam University, Gyeongsan 38541, Republic of Korea

^dResearch Institute of Cell Culture, Yeungnam University, Gyeongsan 38541, Republic of Korea

^eDepartment of Precision Medicine, School of Medicine, Sungkyunkwan University, Suwon 16419, Republic of Korea

^†These authors made equal contributions to this work.

Corresponding author : Pil-Hoon Park

Abstract

Obesity has been known to negatively modulate the life-span and immunosuppressive potential of mesenchymal stromal cells (MSC). However, it remains unclear what drives the compromised potency of obese MSC. In this study, we examined the involvement of adiponectin, an adipose tissue-derived hormone, in obesity-induced impaired therapeutic function of MSC. Diet-induced obesity leads to a decrease in serum adiponectin, accompanied by impairment of survival and immunomodulatory effects of adipose-derived MSC (ADSC). Interestingly, priming with globular adiponectin (gAcrp) improved the immunomodulatory potential of obese ADSC. Similar effects were also observed in lean ADSC. In addition, gAcrp potentiated the therapeutic effectiveness of ADSC in a mouse model of DSS-induced colitis. Mechanistically, while obesity inhibited the glycolytic capacity of MSC, gAcrp treatment induced a metabolic shift toward glycolysis through activation of adiponectin receptor type 1/p38 MAPK/hypoxia inducible factor-1α axis. These findings suggest that activation of adiponectin signaling is a promising strategy for enhancing the therapeutic efficacy of MSC against immune-mediated disorders.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-26)
연구진국내(교신)+국외 연구진
분야 의약학 > 약학

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