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J. Extracell. Vesicles, Jan 2024, 13 (1) | https://doi.org/10.1002/jev2.12407 Extracellular vesicles from periodontal pathogens regulate hepatic steatosis via Toll-like receptor 2 and plasminogen activator inhibitor-1

Hyun Young Kim^1,4, Younggap Lim¹, Ji Sun Jang², Yeon Kyeong Ko³, Youngnim Choi^3,4, Hong-Hee Kim^2,4, Bong-Kyu Choi¹

¹Department of Oral Microbiology and Immunology, School of Dentistry, Seoul National University, Seoul, Republic of Korea

²Department of Cell and Developmental Biology, School of Dentistry, Seoul National University, Seoul, Republic of Korea

³Department of Immunology and Molecular Microbiology, School of Dentistry, Seoul National University, Seoul, Republic of Korea

⁴Dental Research Institute, School of Dentistry, Seoul National University, Seoul, Republic of Korea

Correspondence : Bong-Kyu Choi

Abstract

Plasminogen activator inhibitor-1 (PAI-1) is associated with nonalcoholic fatty liver disease (NAFLD) by lipid accumulation in the liver. In this study, we showed that extracellular vesicles (EVs) from the periodontal pathogens Filifactor alocis and Porphyromonas gingivalis induced steatosis by inducing PAI-1 in the liver and serum of mice fed a low-fat diet. PAI-1 induction was not observed in TLR2 ^-/- mice. When tested using HEK-Blue hTLR2 cells, human TLR2 reporter cells, the TLR2-activating ability of serum from NAFLD patients (n = 100) was significantly higher than that of serum from healthy subjects (n = 100). Correlation analysis confirmed that PAI-1 levels were positively correlated with the TLR2-activating ability of serum from NAFLD patients and healthy subjects. Amphiphilic molecules in EVs were involved in PAI-1 induction. Our data demonstrate that the TLR2/PAI-1 axis is important for hepatic steatosis by EVs of periodontal pathogens.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-23)
연구진국내 연구진
분야 의약학 > 면역의학

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