Leandra Severino (KIST)

한빛사논문

조회231

Leandra SeverinoLeandra Severino

KIST

Neurosci. Biobehav. Rev., Jan 19 2024, S0149-7634(24)00027-7 | https://doi.org/10.1016/j.neubiorev.2024.105559 From synapses to circuits: What mouse models have taught us about how autism spectrum disorder impacts hippocampal function

Leandra Severino^a,b, Jinhyun Kim ^a,b, Min-Ho Nam ^a,b, Thomas J. McHugh ^a,c

^aBrain Science Institute, Korea Institute of Science and Technology (KIST), Seoul, Korea

^bDivision of Bio-Medical Science & Technology, KIST-School, University of Science and Technology, Seoul, Korea

^cLaboratory for Circuit and Behavioral Physiology, RIKEN Center for Brain Science, 2-1 Hirosawa, Wako-shi Saitama, Japan

Corresponding authors: Min-Ho Nam, Thomas J. McHugh

Abstract

Autism spectrum disorder (ASD) is a complex neurodevelopmental disorder that impacts a variety of cognitive and behavioral domains. While a genetic component of ASD has been well-established, none of the numerous syndromic genes identified in humans accounts for more than 1% of the clinical patients. Due to this large number of target genes, numerous mouse models of the disorder have been generated. However, the focus on distinct brain circuits, behavioral phenotypes and diverse experimental approaches has made it difficult to synthesize the overwhelming number of model animal studies into concrete throughlines that connect the data across levels of investigation. Here we chose to focus on one circuit, the hippocampus, and one hypothesis, a shift in excitatory/inhibitory balance, to examine, from the level of the tripartite synapse up to the level of in vivo circuit activity, the key commonalities across disparate models that can illustrate a path towards a better mechanistic understanding of ASD's impact on hippocampal circuit function.

논문정보

형식Review Paper
게재일2024년 01월 (BRIC 등록일 2024-01-23)
연구진국내(교신)+국외 연구진
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