김민환 (University of Basel, 현 Allen Institute for Brain Science) | 한빛사논문 > 한빛사

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조회523

University of Basel, 현 Allen Institute for Brain Science

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Neuron, Jan 17 2024, S0896-6273(23)00972-8 | https://doi.org/10.1016/j.neuron.2023.12.013 Functional specificity of recurrent inhibition in visual cortex

Petr Znamenskiy ^1,2,3,4,9,10, Mean-Hwan Kim ^3,5,9, Dylan R. Muir ^3,6,9, M. Florencia Iacaruso ^3,7, Sonja B. Hofer^2,3,8, Thomas D. Mrsic-Flogel ^2,3,8

¹Specification and Function of Neural Circuits Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK

²Sainsbury Wellcome Centre, 25 Howland Street, London W1T 4JG, UK

³Biozentrum, University of Basel, Klingelbergstrasse 70, 4056 Basel, Switzerland

⁴Present address: Specification and Function of Neural Circuits Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK

⁵Present address: Allen Institute for Brain Science, 615 Westlake Ave N, Seattle, WA 98109, USA

⁶Present address: SysSense, Thurgauerstrasse 60, 8050 Zürich, Switzerland

⁷Present address: Neuronal Circuits and Behaviour Laboratory, The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK

⁸Present address: Sainsbury Wellcome Centre, 25 Howland Street, London W1T 4JG, UK

⁹These authors contributed equally

¹⁰Lead contact

Corresponding authors: Petr Znamenskiy, Thomas D. Mrsic-Flogel

Abstract

In the neocortex, neural activity is shaped by the interaction of excitatory and inhibitory neurons, defined by the organization of their synaptic connections. Although connections among excitatory pyramidal neurons are sparse and functionally tuned, inhibitory connectivity is thought to be dense and largely unstructured. By measuring in vivo visual responses and synaptic connectivity of parvalbumin-expressing (PV+) inhibitory cells in mouse primary visual cortex, we show that the synaptic weights of their connections to nearby pyramidal neurons are specifically tuned according to the similarity of the cells' responses. Individual PV+ cells strongly inhibit those pyramidal cells that provide them with strong excitation and share their visual selectivity. This structured organization of inhibitory synaptic weights provides a circuit mechanism for tuned inhibition onto pyramidal cells despite dense connectivity, stabilizing activity within feature-specific excitatory ensembles while supporting competition between them.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-23)
연구진국외 연구진
분야 생명과학 > 생리학

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