한빛사논문
- 조회273
Jeon, Ok Hwaa,b; Bao, Kaic; Kim, Kyungsua,b; Wang, Haoranc,d; Yokomizo, Shinyac; Park, G. Katec; Cho, Byeong Hyeona; Rho, Jiyuna; Kim, Chungyeule; Choi, Hak Sooc; Kim, Hyun Kooa,b
aDepartment of Thoracic and Cardiovascular Surgery, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea
bDepartment of Biomedical Sciences, College of Medicine, Korea University, Seoul, Republic of Korea
cGordon Center for Medical Imaging, Department of Radiology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA
dWuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, People’s Republic of China
eDepartment of Pathology, Korea University Guro Hospital, College of Medicine, Korea University, Seoul, Republic of Korea
Ok Hwa Jeon , Kai Bao These authors contributed equally
Ok Hwa Jeon and Kai Bao contributed equally to this work and were co-first authors.
*Corresponding authors : Choi, Hak Soo, Kim, Hyun Koo
Abstract
Background: Segmentectomy is a type of limited resection surgery indicated for patients with very early-stage lung cancer or compromised function because it can improve quality of life with minimal removal of normal tissue. For segmentectomy, an accurate detection of the tumor with simultaneous identification of the lung intersegment plane is critical. However, it is not easy to identify both during surgery. Here, we report dual-channel image-guided lung cancer surgery using renally clearable and physiochemically stable targeted fluorophores to visualize the tumor and intersegmental plane distinctly with different colors; cRGD-ZW800 (800 nm channel) targets tumors specifically, and ZW700 (700 nm channel) simultaneously helps discriminate segmental planes.
Methods: The NIR fluorophores with 700 nm and with 800 nm channels were developed and evaluated the feasibility of dual-channel fluorescence imaging of lung tumors and intersegmental lines simultaneously in mouse, rabbit, and canine animal models. Expression levels of integrin αvβ3, which is targeted by cRGD-ZW800-PEG, were retrospectively studied in the lung tissue of 61 patients who underwent lung cancer surgery.
Results: cRGD-ZW800-PEG has clinically useful optical properties and outperforms the FDA-approved NIR fluorophore indocyanine green (ICG) and serum unstable cRGD-ZW800-1 in multiple animal models of lung cancer. Combined with the blood-pooling agent ZW700-1C, cRGD-ZW800-PEG permits dual-channel NIR fluorescence imaging for intraoperative identification of lung segment lines and tumor margins with different colors simultaneously and accurately.
Conclusion: This dual-channel image-guided surgery enables complete tumor resection with adequate negative margins that can reduce the recurrence rate and increase the survival rate of lung cancer patients.
논문정보
- Research article
- 2024년 01월 (BRIC 등록일 2024-01-23)
- 국내(교신)+국외 연구진
- 의약학 > 종양의학
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