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J. Allergy Clin. Immunol., Jan 17 2024, S0091-6749(24)00032-0 | https://doi.org/10.1016/j.jaci.2023.12.024 Allergic rhinitis phenotypes with distinct transcriptome profiles in children: a birth cohort

Youn Ho Shin MD, PhD ^a,†, Jeong-Hyun Kim PhD ^b,†, Si-hyeon Lee PhD ^b, So-Yeon Lee MD, PhD ^c, Yoon Mee Park PhD^b, Eum Ji Choi MD^c, Eun Young Paek MD^d, Kun-Baek Song MD ^e, Min Ji Park MD ^f, Sungsu Jung MD ^g, Jisun Yoon MD ^h, Dong In Suh MD, PhD ⁱ, Kyung Won Kim MD, PhD ^j, Kangmo Ahn MD, PhD ^k, Soo-Jong Hong MD, PhD ^d

^aDepartment of Pediatrics, The Catholic University of Korea, Yeouido St. Mary’s Hospital, Seoul, Republic of Korea

^bDepartment of Medicine, University of Ulsan College of Medicine, Seoul, Republic of Korea

^cDepartment of Pediatrics, Gyeongsang National University Changwon Hospital, Changwon, Republic of Korea

^dDepartment of Pediatrics, Childhood Asthma Atopy Center, Asan Medical Center, University of Ulsan College of Medicine, Seoul, Republic of Korea

^eDepartment of Pediatrics, Soonchunhyang University Cheonan Hospital, Cheonan, Republic of Korea

^fDepartment of Pediatrics, Hallym Sacred Heart Hospital, Anyang, Republic of Korea

^gDepartment of Pediatrics, Pusan National University Yangsan Hospital, Yangsan, Republic of Korea

^hDepartment of Pediatrics, Chung-Ang University Gwangmyeong Hospital, Chung-Ang University College of Medicine, Gwangmyeong, Republic of Korea

ⁱDepartment of Pediatrics, Seoul National University College of Medicine, Seoul, Republic of Korea

^jDepartment of Pediatrics, Yonsei University College of Medicine, Seoul, Republic of Korea

^kDepartment of Pediatrics, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Republic of Korea

Correspondence: Soo-Jong Hong, MD, PhD.

Abstract

Allergic rhinitis (AR) phenotypes in childhood are unclear. To determine AR phenotypes and investigate their natural course and clinical and transcriptomic characteristics. Latent class trajectory analysis was used for phenotyping AR in 1050 children from birth through 12 years using a birth cohort study. Blood transcriptome analyses were performed to define the underlying mechanisms of each phenotype. Five AR phenotypes were identified: early-onset (n=88, 8.4%), intermediate transient (n=110, 10.5%), late-onset (n=209, 19.9%), very late-onset (n=187, 17.8%), and never/infrequent (n=456, 43.4%). Children with early-onset AR were associated with higher AR severity and sensitizations to foods at age 1 and inhalants at age 3 and asthma symptoms, but not with bronchial hyperresponsiveness (BHR). Children with late-onset AR phenotype associated with sensitizations to various foods at age 1, but not from age 3, and to inhalants from age 7 and with asthma with BHR. Children with very late-onset AR phenotype associated with sensitizations to foods throughout preschool age and to inhalants at ages 7 and 9 and with asthma with BHR. Transcriptome analysis showed that early-onset AR was associated with viral/bacterial infection-related defense response, whereas late-onset AR was associated with T cell-related immune response. Early-onset AR phenotype was associated with sensitization to foods and inhalants at an early age and asthma symptoms, but not with BHR, whereas very late- and late-onset AR phenotypes were positively associated with sensitization to inhalants and asthma with BHR. Transcriptomic analyses indicated that early- and late-onset AR phenotypes had distinct underlying mechanisms related to AR as well.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-22)
연구진국내 연구진
분야 의약학 > 면역의학

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