송진원 (고려대학교 의과대학) | 한빛사논문 > 한빛사

한빛사논문

조회342

고려대학교 의과대학

CV File 53 kb

J. Med. Virol., Jan 2024, 96 (1) | https://doi.org/10.1002/jmv.29401 First detection and characterization of hepatitis E virus (Rocahepevirus ratti) from urban Norway rats (Rattus norvegicus) in the Republic of Korea

Kyungmin Park^1,2, Jongwoo Kim ^1,2, Juyoung Noh ^1,2, Kijin Kim ^3,4, Eunyoung Yang^1,2, Seong-Gyu Kim^1,2, Hee-Kyung Cho ^1,2, Kwan Soo Byun⁵, Ji Hoon Kim ⁵, Young-Sun Lee ⁵, Jung Ok Shim ⁶, Minsoo Shin ⁷, Won-Keun Kim ^8,9, Jin-Won Song ^1,2

¹Department of Microbiology, Korea University College of Medicine, Seoul, Republic of Korea.

²BK21 Graduate Program, Department of Biomedical Sciences, Korea University College of Medicine, Seoul, Republic of Korea.

³Centre for Infectious Disease Genomics and One Health, Faculty of Health Sciences, Simon Fraser University, Burnaby, British Columbia, Canada.

⁴Department of Molecular Biology and Biochemistry, Simon Fraser University, Burnaby, British Columbia, Canada.

⁵Department of Internal Medicine, Division of Gastroenterology and Hepatology, Korea University Medical Center, Seoul, Republic of Korea.

⁶Department of Pediatrics, Korea University College of Medicine, Seoul, Republic of Korea.

⁷Department of Pediatrics, Korea University Ansan Hospital, Ansan, Republic of Korea.

⁸Department of Microbiology, College of Medicine, Hallym University, Chuncheon, Republic of Korea.

⁹Institute of Medical Research, College of Medicine, Hallym University, Chuncheon, Republic of Korea.

CORRESPONDING AUTHOR : Jin-Won Song

Abstract

Hepatitis E virus (HEV), an emerging zoonotic pathogen, poses a significant public health concern worldwide. Recently, rat HEV (Rocahepevirus ratti genotype C1; HEV-C1) has been reported to cause zoonotic infections and hepatitis in humans. Human infections with HEV-C1 are considered to be underestimated worldwide due to limited knowledge of transmission routes, genome epidemiology, and the risk assessment of zoonosis associated with these viruses. A total of 186 wild Norway rats (Rattus norvegicus) were collected from the Republic of Korea (ROK) between 2011 and 2021. The prevalence of HEV-C1 RNA was 8 of 180 (4.4%) by reverse-transcription polymerase chain reaction. We first reported three nearly whole-genome sequences of HEV-C1 newly acquired from urban rats in the ROK. Phylogenetic analysis demonstrated that Korea-indigenous HEV-C1 formed an independent genetic group with those derived from R. norvegicus rats in other countries, indicating geographical and genetic diversity. Our findings provide critical insights into the molecular prevalence, genome epidemiology, and zoonotic potential of Rocahepevirus. This report raises awareness of the presence of Rocahepevirus-related hepatitis E among physicians in the ROK.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-22)
연구진국내 연구진
분야

댓글 작성 로그인

CV 열람하기

연락처 보기