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Cell Rep. Med., Jan 16 2024, 5 (1) S2666-3791(23)00614-6 | https://doi.org/10.1016/j.xcrm.2023.101385
Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links
Yi-Jun Kim 1,2, Hyun Guy Kang 3, Jin-Hong Kim 4,5
1Department of Environmental Medicine, College of Medicine, Ewha Womans University, Seoul 07804, South Korea
2Department of Radiation Oncology, College of Medicine, Ewha Womans University, Seoul 07804, South Korea
3Orthopaedic Oncology Clinic, Research Institute and Hospital, National Cancer Center, Goyang 10408, South Korea
4Department of Biological Sciences, College of Natural Sciences, Seoul National University, Seoul 08826, South Korea
5Center for RNA Research, Institute for Basic Science, Seoul 08826, South Korea
Corresponding author: Jin-Hong Kim
Abstract
In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD
+ dependencies for survival.
1 Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.
논문정보
- Backstory
- 2024년 01월 (BRIC 등록일 2024-01-18)
- 국내 연구진
- 생명과학 > 노화/암생물학
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