이근동 (University of California San Diego)

한빛사논문

조회470

이근동Keundong Lee

University of California San Diego

CV File 398 kb

Nat. Commun., 17 January 2024 | https://doi.org/10.1038/s41467-023-43727-9 Flexible, scalable, high channel count stereo-electrode for recording in the human brain

Keundong Lee ^{# 1}, Angelique C Paulk ^{# 2 3}, Yun Goo Ro ^{# 1}, Daniel R Cleary ^{1 4}, Karen J Tonsfeldt ^{1 5}, Yoav Kfir ^{6 7}, John S Pezaris ^{6 7}, Youngbin Tchoe ¹, Jihwan Lee ¹, Andrew M Bourhis ¹, Ritwik Vatsyayan ¹, Joel R Martin ¹, Samantha M Russman ¹, Jimmy C Yang ^{6 7}, Amy Baohan ^{6 7}, R Mark Richardson ^{6 7}, Ziv M Williams ^{6 7}, Shelley I Fried ^{6 7}, U Hoi Sang ¹, Ahmed M Raslan ⁸, Sharona Ben-Haim ⁴, Eric Halgren ⁹, Sydney S Cash ^{2 3}, Shadi A Dayeh ^10,*

¹Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

²Department of Neurology, Harvard Medical School, Boston, MA, 02114, USA.

³Center for Neurotechnology and Neurorecovery, Department of Neurology, Massachusetts General Hospital, Boston, MA, 02114, USA.

⁴Department of Neurological Surgery, University of California San Diego, La Jolla, CA, 92093, USA.

⁵Department of Obstetrics, Gynecology, and Reproductive Sciences, Center for Reproductive Science and Medicine, University of California San Diego, La Jolla, CA, 92093, USA.

⁶Department of Neurosurgery, Harvard Medical School, Boston, MA, 02114, USA.

⁷Department of Neurosurgery, Massachusetts General Hospital, Boston, MA, 02114, USA.

⁸Department of Neurological Surgery, Oregon Health and Science University, Portland, OR, 97239, USA.

⁹Department of Radiology, University of California San Diego, La Jolla, CA, 92093, USA.

¹⁰Integrated Electronics and Biointerfaces Laboratory, Department of Electrical and Computer Engineering, University of California San Diego, La Jolla, CA, 92093, USA.

^#Contributed equally.
^*Corresponding author: correspondence to Shadi A Dayeh

Abstract

Over the past decade, stereotactically placed electrodes have become the gold standard for deep brain recording and stimulation for a wide variety of neurological and psychiatric diseases. Current electrodes, however, are limited in their spatial resolution and ability to record from small populations of neurons, let alone individual neurons. Here, we report on an innovative, customizable, monolithically integrated human-grade flexible depth electrode capable of recording from up to 128 channels and able to record at a depth of 10 cm in brain tissue. This thin, stylet-guided depth electrode is capable of recording local field potentials and single unit neuronal activity (action potentials), validated across species. This device represents an advance in manufacturing and design approaches which extends the capabilities of a mainstay technology in clinical neurology.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-19)
연구진국외 연구진
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