한빛사논문
- 조회300
Jeong Han Lee 1,10, Maria C. Perez-Flores 1,10, Seojin Park 1,2, Hyo Jeong Kim 1, Yingying Chen 1, Mincheol Kang 1,2, Jennifer Kersigo 3, Jinsil Choi 1, Phung N. Thai 4, Ryan L. Woltz 4, Dolores Columba Perez-Flores 1, Guy Perkins 5, Choong-Ryoul Sihn 1, Pauline Trinh 4, Xiao-Dong Zhang 4, Padmini Sirish 4, Yao Dong 6, Wayne Wei Feng 6, Isaac N. Pessah 6, Rose E. Dixon 7, Bernd Sokolowski 8, Bernd Fritzsch 3, Nipavan Chiamvimonvat 4,9 & Ebenezer N. Yamoah 1,*
1Department of Physiology and Cell Biology, School of Medicine, University of Nevada, Reno, NV 89557, USA.
2Prestige Biopharma, 11-12F, 44, Myongjigukje7- ro, Gangseo-gu, Busan 67264, South Korea.
3Department of Biology, University of Iowa, Iowa City, IA, USA.
4Division of Cardiovascular Medicine, Department of Internal Medicine, University of California, Davis, CA 95616, USA.
5National Center for Microscopy and Imaging Research, University of California San Diego, La Jolla, CA 92093, USA.
6Department of Molecular Biosciences, School of Veterinary Medicine, University of California, Davis, 1089 VM3B, Davis, CA 95616, USA.
7Department of Physiology & Membrane Biology, Tupper Hall, One Shields Avenue, Davis, CA 95616, USA.
8Department of Otolaryngology-Head and Neck Surgery, Morsani College of Medicine, University of South Florida, Tampa, FL 33612, USA.
9VA Northern California Healthcare System, Sacramento, USA.
10These authors contributed equally: Jeong Han Lee, Maria C. Perez-Flores.
*Corresponding author: correspondence to Ebenezer N. Yamoah
Abstract
The inner ear is the hub where hair cells (HCs) transduce sound, gravity, and head acceleration stimuli to the brain. Hearing and balance rely on mechanosensation, the fastest sensory signals transmitted to the brain. The mechanoelectrical transducer (MET) channel is the entryway for the sound-balance-brain interface, but the channel-complex composition is not entirely known. Here, we report that the mouse utilizes Piezo1 (Pz1) and Piezo2 (Pz2) isoforms as MET-complex components. The Pz channels, expressed in HC stereocilia, and cell lines are co-localized and co-assembled with MET complex partners. Mice expressing non-functional Pz1 and Pz2 at the ROSA26 locus have impaired auditory and vestibular traits that can only be explained if the Pzs are integral to the MET complex. We suggest that Pz subunits constitute part of the MET complex and that interactions with other MET complex components yield functional MET units to generate HC MET currents.
논문정보
- Research article
- 2024년 01월 (BRIC 등록일 2024-01-29)
- 국외 연구진
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