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연세대학교, 기초과학연구원

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Nat. Nanotechnol., Jan 15 2024, | https://doi.org/10.1038/s41565-023-01587-w Liquid-metal-based three-dimensional microelectrode arrays integrated with implantable ultrathin retinal prosthesis for vision restoration

Won Gi Chung^1,2,3,10, Jiuk Jang^1,2,3,10, Gang Cui^4,10, Sanghoon Lee^1,2,3,10, Han Jeong^4,5, Haisu Kang⁶, Hunkyu Seo^1,2,3, Sumin Kim^1,2,3, Enji Kim^1,2,3, Junwon Lee⁷, Seung Geol Lee^6,8, Suk Ho Byeon^4,5 & Jang-Ung Park^1,2,3,9

¹Department of Materials Science & Engineering, Yonsei University, Seoul, Republic of Korea.

²Center for Nanomedicine, Institute for Basic Science (IBS), Seoul, Republic of Korea.

³Graduate Program of Nano Biomedical Engineering (NanoBME), Advanced Science Institute, Yonsei University, Seoul, Republic of Korea.

⁴Institute of Vision Research, Department of Ophthalmology, Severance Eye Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

⁵Brain Korea 21 Project for Medical Science, Yonsei University College of Medicine, Seoul, Republic of Korea.

⁶School of Chemical Engineering, Pusan National University, Busan, Republic of Korea.

⁷Institute of Vision Research, Department of Ophthalmology, Gangnam Severance Hospital, Yonsei University College of Medicine, Seoul, Republic of Korea.

⁸Department of Organic Material Science and Engineering, Pusan National University, Busan, Republic of Korea.

⁹Department of Neurosurgery, Yonsei University College of Medicine, Seoul, Republic of Korea.

¹⁰These authors contributed equally: Won Gi Chung, Jiuk Jang, Gang Cui, Sanghoon Lee.

These authors contributed equally: Won Gi Chung, Jiuk Jang, Gang Cui, Sanghoon Lee.

Corresponding authors : Correspondence to Seung Geol Lee, Suk Ho Byeon or Jang-Ung Park.

Abstract

Electronic retinal prostheses for stimulating retinal neurons are promising for vision restoration. However, the rigid electrodes of conventional retinal implants can inflict damage on the soft retina tissue. They also have limited selectivity due to their poor proximity to target cells in the degenerative retina. Here we present a soft artificial retina (thickness, 10 μm) where flexible ultrathin photosensitive transistors are integrated with three-dimensional stimulation electrodes of eutectic gallium-indium alloy. Platinum nanoclusters locally coated only on the tip of these three-dimensional liquid-metal electrodes show advantages in reducing the impedance of the stimulation electrodes. These microelectrodes can enhance the proximity to the target retinal ganglion cells and provide effective charge injections (72.84 mC cm ^-2) to elicit neural responses in the retina. Their low Young's modulus (234 kPa), owing to their liquid form, can minimize damage to the retina. Furthermore, we used an unsupervised machine learning approach to effectively identify the evoked spikes to grade neural activities within the retinal ganglion cells. Results from in vivo experiments on a retinal degeneration mouse model reveal that the spatiotemporal distribution of neural responses on their retina can be mapped under selective localized illumination areas of light, suggesting the restoration of their vision.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-17)
연구진국내 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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