신광수 (Yale University, 인하대학교) | 한빛사논문 > 한빛사

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Yale University, 인하대학교

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ACS Nano, Jan 16 2024, | https://doi.org/10.1021/acsnano.3c05921 Nanoscale Surface Topography of Polyethylene Glycol-Coated Nanoparticles Composed of Bottlebrush Block Copolymers Prolongs Systemic Circulation and Enhances Tumor Uptake

Julian Grundler,^†,1,2, Kwangsoo Shin,^†,2,7, HeeWon Suh,², Chang-Hee Whang,², Giulio Fulgoni,³, Richard W. Pierce,³ and W. Mark Saltzman^*,2,4,5,6

¹Department of Chemistry, ²Department of Biomedical Engineering, and ⁶Department of Chemical & Environmental Engineering, Yale University, New Haven, CT 06511 (USA)

³Department of Pediatrics, ⁴Departmentof Cellular & Molecular Physiology and ⁵Department of Dermatology, Yale School of Medicine, New Haven, CT 06510 (USA)

⁷Department of Polymer Science & Engineering and Environmental Engineering, Inha University, Incheon, 22212 (Korea)

^*Corresponding author : W. Mark Saltzman

^†Equal contribution

Abstract

Improving the performance of nanocarriers remains a major challenge in the clinical translation of nanomedicine. Efforts to optimize nanoparticle formulations typically rely on tuning the surface density and thickness of stealthy polymer coatings, such as poly(ethylene glycol) (PEG). Here, we show that modulating the surface topography of PEGylated nanoparticles using bottlebrush block copolymers (BBCPs) significantly enhances circulation and tumor accumulation, providing an alternative strategy to improve nanoparticle coatings. Specifically, nanoparticles with rough surface topography achieve high tumor cell uptake in vivo due to superior tumor extravasation and distribution compared to conventional smooth-surfaced nanoparticles based on linear block copolymers. Furthermore, surface topography profoundly impacts the interaction with serum proteins, resulting in the adsorption of fundamentally different proteins onto the surface of rough-surfaced nanoparticles formed from BBCPs. We envision that controlling the nanoparticle surface topography of PEGylated nanoparticles will enable the design of improved nanocarriers in various biomedical applications.

논문정보

형식Research article
게재일2024년 01월 (BRIC 등록일 2024-01-23)
연구진국내+국외 연구진
분야 바이오·의료융합 > 바이오센싱 및 나노바이오물질

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